Pre-clinical safety of topically administered sunitinib-loaded lipid and polymeric nanocarriers targeting corneal neovascularization

Souza, Leonardo Gomes de; Sousa-Junior, Ailton A.; Cintra, Bertilha Alves Santana; Vieira, Jorge Luís; Nascimento, Thais Leite; Mendes, Lívia Palmerston; Vieira, Marcelo de Souza; Ducas, Rafael do Nascimento; Valadares, Marize Campos; Mendanha, Sebastião Antônio; Lima, Eliana Martins

doi:10.1016/j.ijpharm.2023.122682

Cited by 4 publications

(1 citation statement)

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“…The pre-clinical safety of SLNs was evaluated in polymeric nanospheres and liposomes in a recent study conducted by Gomes Souza et al The authors elaborated sunitinib-loaded nanocarriers as topical formulation strategies for corneal neovascularization treatment. The sunitinib-loaded SLNs were selected as the optimal formulation due to their excellent tolerability profile, controlled drug release, and highest corneal retention [ 165 ].…”

Section: Feasibility Of Lipid Nanoparticles In Ophthalmologymentioning

confidence: 99%

Recent Progress of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Ocular Drug Delivery Platforms

Gugleva

Andonova

2023

Pharmaceuticals

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Sufficient ocular bioavailability is often considered a challenge by the researchers, due to the complex structure of the eye and its protective physiological mechanisms. In addition, the low viscosity of the eye drops and the resulting short ocular residence time further contribute to the observed low drug concentration at the target site. Therefore, various drug delivery platforms are being developed to enhance ocular bioavailability, provide controlled and sustained drug release, reduce the number of applications, and maximize therapy outcomes. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) exhibit all these benefits, in addition to being biocompatible, biodegradable, and susceptible to sterilization and scale-up. Furthermore, their successive surface modification contributes to prolonged ocular residence time (by adding cationic compounds), enhanced penetration, and improved performance. The review highlights the salient characteristics of SLNs and NLCs concerning ocular drug delivery, and updates the research progress in this area.

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Section: Feasibility Of Lipid Nanoparticles In Ophthalmologymentioning

confidence: 99%