Pre-clinical Pharmacokinetic and Metabolomic Analyses of Isorhapontigenin, a Dietary Resveratrol Derivative

Dai, Yu; Yeo, Samuel Chao Ming; Barnes, Peter J.; Donnelly, Louise; Loo, Lai C.; Lin, Hai‐Shu

doi:10.3389/fphar.2018.00753

Cited by 31 publications

(29 citation statements)

References 52 publications

(90 reference statements)

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“…[50]. Interestingly, both ISO and RSV were absorbed rapidly, while better oral pharmacokinetic profile was observed for ISO, and bioavailability was two to three folds greater than that of RSV [50]. These data confirmed that from the pharmacokinetic point of view, ISO is a better candidate for drug development than resveratrol [50].…”

Section: Isorhapontigenin-successor Of Resveratrolsupporting

confidence: 67%

“…Other study showed that one-week daily oral administration of ISO at a dose of 25.8 mg/kg b.w., affected the glucose and plasma cholesterol level, fatty acid biosynthesis, and amino acid/arachidonic acid metabolism. That indicates the health-promoting role of this compound [50].…”

Section: Isorhapontigenin-successor Of Resveratrolmentioning

confidence: 81%

“…Dai et al characterized the pharmacokinetic profile of ISO and RSV in Sprague-Dawley rats after a single oral administration (200 µmol/kg b.w.) [50]. Interestingly, both ISO and RSV were absorbed rapidly, while better oral pharmacokinetic profile was observed for ISO, and bioavailability was two to three folds greater than that of RSV [50].…”

Section: Isorhapontigenin-successor Of Resveratrolmentioning

confidence: 97%

“…Interestingly, both ISO and RSV were absorbed rapidly, while better oral pharmacokinetic profile was observed for ISO, and bioavailability was two to three folds greater than that of RSV [50]. These data confirmed that from the pharmacokinetic point of view, ISO is a better candidate for drug development than resveratrol [50]. It is more important because the low oral bioavailability of RSV (< 1%) due to rapid and extensive metabolism in the intestine and the liver is one of the most drawbacks of this compound [51].…”

Section: Isorhapontigenin-successor Of Resveratrolmentioning

confidence: 99%

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More Than Resveratrol: New Insights into Stilbene-Based Compounds

et al. 2020

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The concept of a scaffold concerns many aspects at different steps on the drug development path. In medicinal chemistry, the choice of relevant “drug-likeness” scaffold is a starting point for the design of the structure dedicated to specific molecular targets. For many years, the chemical uniqueness of the stilbene structure has inspired scientists from different fields such as chemistry, biology, pharmacy, and medicine. In this review, we present the outstanding potential of the stilbene-based derivatives. Naturally occurring stilbenes, together with powerful synthetic chemistry possibilities, may offer an excellent approach for discovering new structures and identifying their therapeutic targets. With the development of scientific tools, sophisticated equipment, and a better understanding of the disease pathogenesis at the molecular level, the stilbene scaffold has moved innovation in science. This paper mainly focuses on the stilbene-based compounds beyond resveratrol, which are particularly attractive due to their biological activity. Given the “fresh outlook” about different stilbene-based compounds starting from stilbenoids with particular regard to isorhapontigenin and methoxy- and hydroxyl- analogues, the update about the combretastatins, and the very often overlooked and underestimated benzanilide analogues, we present a new story about this remarkable structure.

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Section: Isorhapontigenin-successor Of Resveratrolsupporting

confidence: 67%

Section: Isorhapontigenin-successor Of Resveratrolmentioning

confidence: 81%

Section: Isorhapontigenin-successor Of Resveratrolmentioning

confidence: 97%

Section: Isorhapontigenin-successor Of Resveratrolmentioning

confidence: 99%

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More Than Resveratrol: New Insights into Stilbene-Based Compounds

et al. 2020

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“…A total of eight stilbenes in the tubers of G. conopsea extract were identified in positive and negative ion modes. According to their molecular mass, formula, MS/MS fragments, and related literature studies, compounds 38, 39, 40, 57, 64, 69, 72, 73, and 76 were considered to be isorhapontigenin [18], rhaponticin [19], piceatannol [20], dihydro-resveratrol [21], batatasin III [22], 3,3′-dihydroxy-4-(4-hydroxybenzyl)-5-methoxybibenzyl [23], bulbocodin C [24], bulbocodin D [24], and 3,3′-dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl [25], respectively.…”

Section: Stilbenesmentioning

confidence: 99%

Rapid Characterizaiton of Chemical Constituents of the Tubers of Gymnadenia conopsea by UPLC–Orbitrap–MS/MS Analysis

et al. 2020

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Gymnadenia conopsea R. Br. is a traditional Tibetan medicinal plant that grows at altitudes above 3000 m, which is used to treat neurasthenia, asthma, coughs, and chronic hepatitis. However, a comprehensive configuration of the chemical profile of this plant has not been reported because of the complexity of its chemical constituents. In this study, a rapid and precise method based on ultra-high performance liquid chromatography (UPLC) combined with an Orbitrap mass spectrometer (UPLC–Orbitrap–MS/MS) was established in both positive- and negative-ion modes to rapidly identify various chemical components in the tubers of G. conopsea for the first time. Finally, a total of 91 compounds, including 17 succinic acid ester glycosides, 9 stilbenes, 6 phenanthrenes, 19 alkaloids, 11 terpenoids and steroids, 20 phenolic acid derivatives, and 9 others, were identified in the tubers of G. conopsea based on the accurate mass within 3 ppm error. Furthermore, many alkaloids, phenolic acid derivates, and terpenes were reported from G. conopsea for the first time. This rapid method provides an important scientific basis for further study on the cultivation, clinical application, and functional food of G. conopsea.

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