Pre-clinical investigation of liquid sirolimus for local drug delivery
Meagan Todd,
Linda B. Liu,
Justin M. Saul
et al.
Abstract:IntroductionSirolimus is currently being explored as an alternative drug to paclitaxel for the treatment of peripheral artery disease (PAD). To date, sirolimus has only been used as drug coatings for stents and balloons and no studies have yet demonstrated the delivery of sirolimus in liquid form. The purpose of this pilot study was to investigate the feasibility of the delivery of liquid sirolimus into arterial segments in a benchtop peripheral artery bioreactor.MethodsThe feasibility to deliver liquid therap… Show more
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