Pre-clinical and clinical studies of a novel porous biphasic calcium phosphate ceramic as alternative to repair bone defects

Abstract

RICARDO QUÍRICO PINHEIRO MACHADO Pre-clinical and clinical studies of a novel porous biphasic calcium phosphate ceramic as alternative to repair bone defectsEstudos pré-clínico e clínico de uma nova cerâmica bifásica porosa de fosfato de cálcio como uma alternativa para o reparo de defeitos ósseos BAURU 2018 BAURU 2018 ABSTRACT Objectives: We compared a novel porous biphasic calcium phosphate (pBCP) containing 70% HA and 30% β-TCP with autogenous bone (AB) regarding bone formation, graft granular size influence (0.7, 1.0 or 1.5 mm), physicochemical properties, and volumetric changes of the total grafted area as well its components (newly formed bone, graft particle stability and soft tissue). Materials and methods: Article 1 used a critical size defect in rats.Analyzes included XRD (X-ray diffraction), SEM (scanning electron microscope) and EDS