Pre-bypass quality assessment of the long saphenous vein wall with ultrasound and histology

Giannoukas, Athanasios D.; Labropoulos, Nicos; Stavridis, George; Bailey, David; Glenville, Brian; An, Nicolaides

doi:10.1016/s1078-5884(97)80223-7

Cited by 23 publications

(21 citation statements)

References 21 publications

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“…Then again, GSVs used for coronary artery bypass grafting have also some degree of pre-existing fibrotic changes in the wall. 27 The vascular endothelium has a crucial role in the regulation of vascular homeostasis by controlling coagulation, inflammatory responses, and vascular tone. Estradiol may influence the vascular reactivity 28 due to increased nitric oxide (NO) expression and increase NO production and subsequent vasorelaxation.…”

Section: Discussionmentioning

confidence: 99%

Elevated sex steroid hormones in great saphenous veins in men

Kendler

Makrantonaki

Kratzsch

et al. 2010

Journal of Vascular Surgery

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Elevated serum estradiol and testosterone levels were detected in men with varicose veins and reflux in the GSV compared with the patient's own arm veins. Enzymes and hormonal receptors involved in steroid metabolism were down-regulated in patients with GSV reflux and varicose veins, suggestive of a negative feedback regulation. These data support the notion of a possible causal relationship between sex steroids and varicose veins in men.

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Section: Discussionmentioning

confidence: 99%

Elevated sex steroid hormones in great saphenous veins in men

Kendler

Makrantonaki

Kratzsch

et al. 2010

Journal of Vascular Surgery

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“…Although the IMA is a sound graft, this study focuses on the pathological role of ET-1 and receptors in abnormal vessel wall remodeling, and as such, it essentially used the IMA as an in situ model. Giannoukas and colleagues 18 have demonstrated that ultrasound evaluation and histology of the long saphenous vein do not correlate and have shown that ultrasound was only effective in detecting Ϸ10% of moderate/severe fibrosis in this vessel. This study is novel in that it additionally evaluates structural and cellular abnormalities in association with ET-1, a pathological and potential preclinical marker of atherogenesis that is well known for its association with endothelial dysfunction.…”

Section: Editorial P 1156 Clinical Perspective P 1188mentioning

confidence: 99%

Vascular Remodeling in the Internal Mammary Artery Graft and Association With In Situ Endothelin-1 and Receptor Expression

et al. 2006

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Background-The vasoconstricting peptide endothelin-1 (ET-1) has been associated with atherosclerotic cardiovascular disease, vascular smooth muscle cell (VSMC) growth stimulation, and intimal thickening. 20%, Pϭ0.0067, respectively). A mild presence of macrophages was noted in all sections. Conclusions-Elevated distribution of collagen indicative of fibrosis coupled with increased cell cycling and high levels of ET-1 and ET A expression in the absence of chronic inflammation suggests altered IMA VSMC regulation is fundamental to the remodeling process.

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“…Handling of the surgically harvested vein is a strong outcome determinant (Conte 2009;Santo et al 2013). Preimplantation histological analysis has been proposed (Giannoukas et al 1997). External sheathing and brachytherapy failed to prevent NH (Kohler et al 1989).…”

Section: Introductionmentioning

confidence: 99%

Neointimal hyperplasia in allogeneic and autologous venous grafts is not different in nature

Albert

Hartmann

Wagner

et al. 2015

Histochem Cell Biol

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Neointimal hyperplasia, transplant rejection and thus immunogenicity of allografts are possible reasons for poorer patency rates in cryopreserved venous allografts for peripheral bypass surgery in comparison with autologous venous grafts. To expand the limited knowledge from human allografts, we histologically investigated allogeneic and autologous venous grafts in arterial location. Specimens of allogeneic and autologous venous graft stenosis, harvested 6 months after bypass implantation, were immunohistochemically characterized. Examination of the lesions showed a uniform morphological pattern. A continuous endothelial layer, tissue fibrosis and a thickened neointima with monocytes and dedifferentiated vascular smooth muscle cells were seen in both conduits with very low cell turnover and the absence of acute and chronic inflammation. Neoangiogenesis with CD34-positive endothelium was abundant in the vessel media. The morphological patterns of allogeneic and autologous neointima formation are similar. Consequently, neointimal hyperplasia in venous grafts may reflect a uniform physiological host response of non-immunological factors with the reasons for poorer clinical outcome of cryopreserved allografts yet to be elucidated.

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Pre-bypass quality assessment of the long saphenous vein wall with ultrasound and histology

Abstract: Pre-existing wall changes are very common in vein grafts used for bypass surgery. However, the ultrasonic characterisation of the venous wall preoperatively cannot reliably identify these changes.

Cited by 23 publications

References 21 publications

Elevated sex steroid hormones in great saphenous veins in men

Elevated sex steroid hormones in great saphenous veins in men

Vascular Remodeling in the Internal Mammary Artery Graft and Association With In Situ Endothelin-1 and Receptor Expression

Neointimal hyperplasia in allogeneic and autologous venous grafts is not different in nature

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