Pre-Attentive Auditory Processing in Ultra-High-Risk for Schizophrenia with Magnetoencephalography

Shin, Kyoo Ho; Kim, June Sic; Kang, Do‐Hyung; Koh, Yul; Choi, Jung Seok; O’Donnell, Brian F.; Chung, Chun Kee; Kwon, Jun Soo

doi:10.1016/j.biopsych.2008.12.024

Cited by 85 publications

(79 citation statements)

References 64 publications

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“…However, the relationship between MMN and functional status, especially GAF scores, is a well-replicated finding within schizophrenia [27,112]. Other studies have reported no significant correlation between duration MMN and GAF in UHR [35,39,43,104], but see [34]. The absence of this correlation within the UHR sample challenges the notion of UHR individuals being a homogenous group representative of those in an early stage of psychosis.…”

Section: Discussioncontrasting

confidence: 38%

114. Electrophysiological, Cognitive and Clinical Profiles of At-Risk Mental State: The Longitudinal Minds in Transition (MinT) Study

Schall¹,

Fulham²,

Atkinson³

et al. 2017

Biological Psychiatry

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The onset of schizophrenia is typically preceded by a prodromal period lasting several years during which sub-threshold symptoms may be identified retrospectively. Clinical interviews are currently used to identify individuals who have an ultra-high risk (UHR) of developing a psychotic illness with a view to provision of interventions that prevent, delay or reduce severity of future mental health issues. The utility of bio-markers as an adjunct in the identification of UHR individuals is not yet established. Several event-related potential measures, especially mismatch-negativity (MMN), have been identified as potential biomarkers for schizophrenia. In this 12-month longitudinal study, demographic, clinical and neuropsychological data were acquired from 102 anti-psychotic naive UHR and 61 healthy controls, of whom 80 UHR and 58 controls provided valid EEG data during a passive auditory task at baseline. Despite widespread differences between UHR and controls on demographic, clinical and neuropsychological measures, MMN and P3a did not differ between these groups. Of 67 UHR at the 12-month follow-up, 7 (10%) had transitioned to a psychotic illness. The statistical power to detect differences between those who did or did not transition was limited by the lower than expected transition rate. ERPs did not predict transition, with trends in the opposite direction to that predicted. In exploratory analysis, the strongest predictors of transition were measures of verbal memory and subjective emotional disturbance.

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Section: Discussioncontrasting

confidence: 38%

114. Electrophysiological, Cognitive and Clinical Profiles of At-Risk Mental State: The Longitudinal Minds in Transition (MinT) Study

Schall¹,

Fulham²,

Atkinson³

et al. 2017

Biological Psychiatry

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“…This may particularly benefit from a computational modeling approach, which uses physiologically interpretable model parameters for clinical predictions (Stephan et al, 2006). In relation to this, recent studies demonstrated that a reduction of MMN can predict the transition of 'ultra-high risk' to first-episode psychosis (Bodatsch et al, 2010;Shin et al, 2009). Finally, the assessment of the MMN memory trace effect may also provide a promising tool to assess the efficacy of novel pharmacological treatment, in particular for treatment of cognitive impairments.…”

Section: S-ketamine-induced Cognitive Impairmentsmentioning

confidence: 99%

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Schmidt

Bachmann

Kometer

et al. 2011

Neuropsychopharmacol

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Psychotomimetics like the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine and the 5-hydroxytryptamine2A receptor (5-HT 2A R) agonist psilocybin induce psychotic symptoms in healthy volunteers that resemble those of schizophrenia. Recent theories of psychosis posit that aberrant encoding of prediction errors (PE) may underlie the expression of psychotic symptoms. This study used a roving mismatch negativity (MMN) paradigm to investigate whether the encoding of PE is affected by pharmacological manipulation of NMDAR or 5-HT 2A R, and whether the encoding of PE under placebo can be used to predict drug-induced symptoms. Using a doubleblind within-subject placebo-controlled design, S-ketamine and psilocybin, respectively, were administrated to two groups of healthy subjects. Psychological alterations were assessed using a revised version of the Altered States of Consciousness (ASC-R) questionnaire. As an index of PE, we computed changes in MMN amplitudes as a function of the number of preceding standards (MMN memory trace effect) during a roving paradigm. S-ketamine, but not psilocybin, disrupted PE processing as expressed by a frontally disrupted MMN memory trace effect. Although both drugs produced positive-like symptoms, the extent of PE processing under placebo only correlated significantly with the severity of cognitive impairments induced by S-ketamine. Our results suggest that the NMDAR, but not the 5-HT 2A R system, is implicated in PE processing during the MMN paradigm, and that aberrant PE signaling may contribute to the formation of cognitive impairments. The assessment of the MMN memory trace in schizophrenia may allow detecting early phases of the illness and might also serve to assess the efficacy of novel pharmacological treatments, in particular of cognitive impairments.

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“…Standard tones (probability 81.8%, duration 50 ms) and deviant tones (probability 18.2%, duration 100 ms) were presented to participants in pseudorandom order (Shin et al, 2009). During recording, subjects were instructed to ignore the sounds and to look at a series of picture slides presented by a video projector from outside the shielded room to divert attention from the auditory stimuli and reduce eye movements (Light and Braff, 2005;Shin et al, 2009).…”

Section: Passive Auditory Oddball Paradigmmentioning

confidence: 99%

“…In multiple clinical groups of, for example, schizophrenia and bipolar disease, MMN dysfunction has been demonstrated to be associated with aberrant pre-attentive auditory processing (Shin et al, 2009(Shin et al, , 2012Näätänen et al, 2011). However, no MMN studies have been conducted specifically in FM.…”

Section: Introductionmentioning

confidence: 95%

“…The data of one FM patient were excluded from the analyses because of excessive epoch rejection due to signal contamination by eye movement. For standard stimuli, the last standard tone, which immediately preceded each deviant tone, was used as a standard stimulus (Shin et al, 2009). At least 165 artifact-free epochs were averaged for each standard and deviant stimuli and filtered using a low pass of 30 Hz.…”

Section: Data Analysesmentioning

confidence: 99%

See 1 more Smart Citation

Impaired pre-attentive auditory processing in fibromyalgia: A mismatch negativity (MMN) study

Choi

Lim

Kim

et al. 2015

Clinical Neurophysiology

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Pre-Attentive Auditory Processing in Ultra-High-Risk for Schizophrenia with Magnetoencephalography

Cited by 85 publications

References 64 publications

114. Electrophysiological, Cognitive and Clinical Profiles of At-Risk Mental State: The Longitudinal Minds in Transition (MinT) Study

114. Electrophysiological, Cognitive and Clinical Profiles of At-Risk Mental State: The Longitudinal Minds in Transition (MinT) Study

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Impaired pre-attentive auditory processing in fibromyalgia: A mismatch negativity (MMN) study

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