Pre-attentive auditory change detection for rapid auditory transient combinations: Insight from age-related processing changes

Volosin, Márta; Czigler, István; Horváth, János

doi:10.1016/j.biopsycho.2021.108024

Cited by 1 publication

(1 citation statement)

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“…This phenomenon, referred as N1 facilitation, has been hypothesized as caused by several factors: (1) an accelerated decay of inhibitory over excitatory postsynaptic potentials at high (<200 ms) stimulation rates (Loveless et al, 1989); (2) avoiding a latent inhibitory feedback from N1 generators if stimulus is presented before inhibition takes place (Sable et al, 2004); (3) a separate neural component with a time course overlapping N1 and P2 that is modulated exclusively by very short ISI (Wang et al, 2008). Some evidence supports this overlapping component may be Mismatch Negativity (Volosin et al, 2017(Volosin et al, , 2021. Our results best fit the third hypothesis, as P2 in addition to N1 followed a different pattern of results under our shortest ISI, reduced more prominently than for other ISIs.…”

Section: Long-latency Responsementioning

confidence: 99%

Intensity and inter‐stimulus‐interval effects on human middle‐ and long‐latency auditory evoked potentials in an unpredictable auditory context

et al. 2022

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It is not known how Auditory‐Evoked Responses (AERs) comprising Middle Latency Responses (MLRs) and Long Latency Responses (LLRs) are modulated by stimulus intensity and inter‐stimulus interval (ISI) in an unpredictable auditory context. Further, intensity and ISI effects on MLR and LLR have never been assessed simultaneously in the same humans. To address this important question, thirty participants passively listened to a random sequence of auditory clicks of three possible intensities (65, 75, and 85 dB) at five possible ISI ranges (0.25 to 0.5 s, 0.5 to 1 s, 1 to 2 s, 2 to 4 s, 4 to 8 s) over four to seven one‐hour sessions while EEG was recorded. P0, Na, Pa, Nb, and Pb MLR peaks and N1 and P2 LLR peaks were measured. MLRs P0 (p = .005), Pa (p = .021), and Pb (p = <.001) were modulated by intensity, while only MLR Pb (p = <.001) was modulated by ISI. LLR N1 and P2 were modulated by both intensity and ISI (all p values < .001). Intensity and ISI interacted at Pb, N1, and P2 (all p values < .001), with greater intensity effects at longer ISIs and greater ISI effects at louder intensities. Together, these results provide a comprehensive picture of intensity and ISI effects on AER across the entire thalamocortical auditory pathway, while controlling for stimulus predictability. Moreover, they highlight P0 as the earliest MLR response sensitive to stimulus intensity and Pb (~50 ms) as the earliest cortical response coding for ISIs above 250 ms and showing an interdependence between intensity and ISI effects.

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