Pre- and Perinatal Risk Factors for Autism Spectrum Disorder in a New Jersey Cohort

Maramara, Lauren A.; He, Wenzhuan; Ming, Xue

doi:10.1177/0883073813512899

Cited by 49 publications

(40 citation statements)

References 32 publications

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“…Ornoy et al (2015) reviewed ASD environmental risk factors and reported 17 significant prenatal, perinatal, and postnatal risk factors: maternal inflammation and immune activation, rubella, cytomegalovirus (CMV), influenza, fever, diabetes, folic acid deficiency, toxoplasmosis; exposure to ethanol, cocaine, valproic acid, misoprostol, thalidomide, antidepressant serotonin reuptake inhibitors (SSRIs); and exposure to pesticides, insecticides, and air pollution. Also, Maramara et al (2014) found 15 significant ASD prenatal, perinatal, and postnatal risk factors in a single study sample: father's age, mother's age, maternal drug and alcohol use, maternal hypertension during pregnancy, gestational diabetes, vaginal bleeding, cesarean section, prematurity, induced labor, prolonged labor, lack of infant oxygen during delivery, low birth weight, newborn jaundice, and newborn infection.…”

Section: Environmental Syndromic Asd Has Been Found With Varied Brainmentioning

confidence: 94%

“…There are fewer defined environmental ASD syndromes than genetic ASD syndromes, but there are numerous ASD environmental risk factors (Boukhris et al 2015;Croen et al 2011;Grabrucker 2013;Hviid et al 2013;Lyall et al 2014;Maramara et al 2014;Ornoy et al 2015;Rossignol et al 2014;Schieve et al 2014). Ornoy et al (2015) reviewed ASD environmental risk factors and reported 17 significant prenatal, perinatal, and postnatal risk factors: maternal inflammation and immune activation, rubella, cytomegalovirus (CMV), influenza, fever, diabetes, folic acid deficiency, toxoplasmosis; exposure to ethanol, cocaine, valproic acid, misoprostol, thalidomide, antidepressant serotonin reuptake inhibitors (SSRIs); and exposure to pesticides, insecticides, and air pollution.…”

Section: Environmental Syndromic Asd Has Been Found With Varied Brainmentioning

confidence: 99%

“…While evidence suggests that gene variants are the dominant cause of the pathophysiology of ASD symptoms, just as gene variants have been found to be the dominant cause for most human traits and disorders (Polderman et al 2015), there are significant findings for many ASD environmental risk factors (Boukhris et al 2015;Grabrucker 2013;Lyall et al 2014;Maramara et al 2014;Ornoy et al 2015;Rossignol et al 2014;Schieve et al 2014). Moreover, heritability studies have variably calculated ASD environmental risk factor influence at 7 to 35 % (Tick et al 2016), 5 to 44 % (Colvert et al 2015), 50 % (Sandin et al 2014), and 55 % (Hallmayer et al 2011).…”

Section: Brain Validity Research Approach 5: Do Multiple Asd Genes DImentioning

confidence: 99%

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ASD Validity

Waterhouse

London

Gillberg

2016

Rev J Autism Dev Disord

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ASD research is at an important crossroads. The ASD diagnosis is important for assigning a child to early behavioral intervention and explaining a child's condition. But ASD research has not provided a diagnosis-specific medical treatment, or a consistent early predictor, or a unified life course. If the ASD diagnosis also lacks biological and construct validity, a shift away from studying ASD-defined samples would be warranted. Consequently, this paper reviews recent findings for the neurobiological validity of ASD, the construct validity of ASD diagnostic criteria, and the construct validity of ASD spectrum features. The findings reviewed indicate that the ASD diagnosis lacks biological and construct validity. The paper concludes with proposals for research going forward.Keywords DSM-5 . ASD . Autism . Diagnosis . Validity . Comorbidity . HeterogeneityThe goal of the DSM-3 nosology (American Psychiatric Association 1980) was to create reliable and standard categorical psychiatric diagnoses (Robins and Guze 1970). However, in the past 30 years, clinical, genetics, and neuroscience findings have revealed that the DSM diagnoses are not biologically valid. The National Institutes of Mental Health (NIMH) responded by proposing the Research Domain Criteria (RDoC) framework for a brain-based transdiagnostic psychiatric symptom nosology (Cuthbert and Insel 2013;Insel et al. 2010;Lilienfeld and Treadway 2016). Peterson (2015) and Weinberger et al. (2015) argued that the RDoC could not replace the DSM-5 psychiatric nosology (American Psychiatric Association 2013) or the parallel International Classification of Diseases (ICD) psychiatric nosology (World Health Organization 2012). But BFor the foreseeable future, RDoC is not envisioned as a system of psychiatric classification in its own right. Instead, in the near term, RDoC and DSM-ICD are expected to coexist. Nevertheless, RDoC is intended to provide scaffolding for a large-scale research program that will ultimately yield an alternative to DSM-ICD^ (Lilienfeld and Treadway 2016, p. 445).RDoC advocates accept that DSM-5/ICD psychiatric categories remain necessary in clinical practice, but argue that researchers should shift to RDoC study designs immediately. They assert that studying psychiatric categories lacking biological validity blocks the discovery of brain bases for psychopathology and thus cannot lead to effective medical treatments for specific psychiatric symptoms (Cuthbert and Insel 2013;Insel et al. 2010;Lilienfeld and Treadway 2016;Yee et al. 2015). Against this RDoC imperative for biological validity, Weinberger et al. (2015) countered that current DSM-5 psychiatric behavioral diagnoses were valid when they yielded effective medical treatment, clear prognosis, and a life course specific to a diagnosis.Autism spectrum disorder (ASD) research has been productive (Dawson 2016;de la Torre-Ubieta et al. 2016;Szatmari et al. 2016), but no ASD research findings have met the validity criteria of Weinberger et al. (2015). DSM-5 ASD research has found no s...

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Section: Environmental Syndromic Asd Has Been Found With Varied Brainmentioning

confidence: 94%

Section: Environmental Syndromic Asd Has Been Found With Varied Brainmentioning

confidence: 99%

Section: Brain Validity Research Approach 5: Do Multiple Asd Genes DImentioning

confidence: 99%

See 1 more Smart Citation

ASD Validity

Waterhouse

London

Gillberg

2016

Rev J Autism Dev Disord

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“…In addition, premature birth further increases the risk of autism spectrum disorders in patients without known autism-related genetic mutations [3]. A recent epidemiological report singles out hypoxia at birth as the only risk factor significantly more prevalent in older mothers of the children with autism spectrum disorders compared to younger mothers [6]. …”

Section: Introductionmentioning

confidence: 99%

Dysregulation of FMRP/mTOR Signaling Cascade in Hypoxic-Ischemic Injury of Premature Human Brain

et al. 2015

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In this study we investigated whether dysregulation of the fragile X mental retardation protein (FMRP) and mammalian target of rapamycin (mTOR) signaling cascade may have a role in the pathogenesis of encephalopathy of prematurity following perinatal hypoxia-ischemia. We examined the brain tissue of newborns with encephalopathy and compared it to age-matched controls with normal brain development and adults. In normal controls, the FMRP expression in cortical grey matter spiked 4-fold during 36-39 gestational weeks compared to the adult, with a concomitant suppression of p70S6K and S6. In encephalopathy cases, the developmental spike of FMRP was not observed, and FMRP levels remained significantly lower than in normal controls. Importantly, this FMRP downregulation was followed by a significant overexpression of p70S6K and S6. Our novel findings thus suggest that premature hypoxic-ischemic brain injury may affect the FMRP/mTOR pathway, as otherwise observed in inherited syndromes of cognitive disability and autism spectrum disorders.

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“…Cytokines also influence neuronal proliferation and differentiation, which is also related to ASD (40). The increased risk has also been confirmed for preeclampsia and pregnancy bleeding, before the 20 th gestational week (38,41). In a systematic review done in 2012, the factors identified as main pregnancy-related ASD risk factors were pregnancy bleeding and preeclampsia (28).…”

Section: Maternal State/pregnancy Complicationsmentioning

confidence: 97%

Perinatal complications, environmental factors and autism spectrum disorders

Mandic-Maravic¹,

Pejović-Milovančević²,

Gazibara³

et al. 2016

Med podmladak

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Objectives: Autism spectrum disorders (ASD) are characterized by qualitative impairment of social interactions, impairment of verbal and nonverbal communication, as well as restricted interests and repetitive behavior. ASD represent a group of complex psychiatric disorders, with both genetic and environmental factors implicated in their etiology. Recent neuroanatomical and epidemiological studies point out to prenatal and early postnatal genesis of ASD. Aim: In this review, we present recent studies that explored the effect of environmental, prenatal and perinatal risk factors on development of ASD. Also, we point out those factors that have been proven to have the strongest association with ASD, and emphasize a very complex interaction of individual factors that might eventually lead to manifestation of this group of disorders. Conclusion: A precise defining of risk factors might provide more insight not only into etiology of ASD, but might also give us a possibility for early recognition and possible prevention of autism spectrum disorders, especially in susceptible individuals. It is also a first step in defining the basis of the gene-environment interaction mechanism, which might enable the development of an individualized therapeutic approach for this group of disorders.

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Pre- and Perinatal Risk Factors for Autism Spectrum Disorder in a New Jersey Cohort

Cited by 49 publications

References 32 publications

ASD Validity

ASD Validity

Dysregulation of FMRP/mTOR Signaling Cascade in Hypoxic-Ischemic Injury of Premature Human Brain

Perinatal complications, environmental factors and autism spectrum disorders

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