Pre-and Perinatal Endocrinology

Melatonin and the human gonadotrophin-releasing hormone pulse generator

“…'The period from late infancy until the onset of puberty may be considered as a state of physiological hypogonadotrophic hypogonadism' (Waldhauser & Steger, 1986). 'The increase of the pulsatile secretion of GnRH is sufficient for explaining the onset of puberty' (Sizonenko & Aubert, 1986). Hence, puberty can be defined as a tardy reactivation of the GnRH pulse generator.…”