Pre-administration of low-dose methamphetamine enhances movement and neural activity after high-dose methamphetamine administration in the striatum

Takeichi, Toshiaki; Hori, Osamu; Hattori, Tsuyoshi; Kiryu, Kyoka; Zuka, Masahiko; Kitamura, Osamu

doi:10.1016/j.neulet.2019.03.023

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…As previously described by other authors, an acute m‐amph injection increased both evoked DA release and reuptake time 38 . M‐amph increases DA release through different mechanisms such as disruption of the dopamine transporter (DAT), 39 and increased DA synthesis after sub‐toxic doses (<2.5 mg/kg) 40,41 …”

Section: Discussionsupporting

confidence: 60%

“…34,35 Perez-Caballero and colleagues 36 39 and increased DA synthesis after sub-toxic doses (<2.5 mg/kg). 40,41 Like the saline group, m-amph-treated animals did not show any significant difference between evoked DA post-sham to baseline. Interestingly, the time to DA reuptake was increased after sham when compared to the baseline in this group.…”

Section: Immunohistochemistrymentioning

confidence: 72%

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Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

Varela,

Boschen,

Yates

et al. 2024

Bipolar Disorders

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BackgroundTreatment of refractory bipolar disorder (BD) is extremely challenging. Deep brain stimulation (DBS) holds promise as an effective treatment intervention. However, we still understand very little about the mechanisms of DBS and its application on BD.AimThe present study aimed to investigate the behavioural and neurochemical effects of ventral tegmental area (VTA) DBS in an animal model of mania induced by methamphetamine (m‐amph).MethodsWistar rats were given 14 days of m‐amph injections, and on the last day, animals were submitted to 20 min of VTA DBS in two different patterns: intermittent low‐frequency stimulation (LFS) or continuous high‐frequency stimulation (HFS). Immediately after DBS, manic‐like behaviour and nucleus accumbens (NAc) phasic dopamine (DA) release were evaluated in different groups of animals through open‐field tests and fast‐scan cyclic voltammetry. Levels of NAc dopaminergic markers were evaluated by immunohistochemistry.ResultsM‐amph induced hyperlocomotion in the animals and both DBS parameters reversed this alteration. M‐amph increased DA reuptake time post‐sham compared to baseline levels, and both LFS and HFS were able to block this alteration. LFS was also able to reduce phasic DA release when compared to baseline. LFS was able to increase dopamine transporter (DAT) expression in the NAc.ConclusionThese results demonstrate that both VTA LFS and HFS DBS exert anti‐manic effects and modulation of DA dynamics in the NAc. More specifically the increase in DA reuptake driven by increased DAT expression may serve as a potential mechanism by which VTA DBS exerts its anti‐manic effects.

show abstract

Section: Discussionsupporting

confidence: 60%

Section: Immunohistochemistrymentioning

confidence: 72%

Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

Varela,

Boschen,

Yates

et al. 2024

Bipolar Disorders

View full text Add to dashboard Cite

show abstract

“…As previously described by other authors, an acute m-amph injection increased both evoked DA release and reuptake time (38). M-amph increases DA release through different mechanisms such as disruption of the dopamine transporter (DAT) (39), and increased DA synthesis after sub-toxic doses (<2.5mg/kg) (40, 41).…”

Section: Discussionmentioning

confidence: 99%

Anti-manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

Varela,

Boschen,

Yates

et al. 2023

Preprint

View full text Add to dashboard Cite

Treatment of refractory bipolar disorder (BD) is extremely challenging. Deep brain stimulation (DBS) holds promise as an effective treatment intervention. However, we still understand very little about the mechanisms of DBS and its application on BD. The present study aimed to investigate the behavioural and neurochemical effects of ventral tegmental area (VTA) DBS in an animal model of mania induced by methamphetamine (m-amph). Wistar rats were given 14 days of m-amph injections, in the last day animals were submitted to 20 minutes of VTA DBS in two different patterns: intermittent low frequency stimulation (LFS) or continuous high frequency stimulation (HFS). Immediately after DBS, manic-like behaviour and nucleus accumbens (NAc) phasic dopamine (DA) release were evaluated separately through open-field test and fast-scan cyclic voltammetry. Levels of NAc dopaminergic markers were evaluated by immunohistochemistry. M-amph induced hyperlocomotion in the animals and both DBS parameters reversed this alteration. M-amph increased DA reuptake time post-sham compared to baseline levels, and both LFS and HFS were able to block this alteration. LFS was also able to reduce phasic DA release when compared to baseline. LFS was able to increase dopamine transporter (DAT) expression in the NAc. These results demonstrate that both VTA LFS and HFS DBS exert anti-manic effects and modulation of DA dynamics in the NAc. More specifically the increase in DA reuptake driven by increased DAT expression may serve as a potential mechanism by which VTA DBS exerts its anti-manic effects.

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Modeling methamphetamine use disorder and relapse in animals: Short- and long-term epigenetic, transcriptional., and biochemical consequences in the rat brain

Elhadi,

Daiwile,

Cadet

2023

Neuroscience & Biobehavioral Reviews

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Pre-administration of low-dose methamphetamine enhances movement and neural activity after high-dose methamphetamine administration in the striatum

Cited by 5 publications

References 24 publications

Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

Anti-manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

Modeling methamphetamine use disorder and relapse in animals: Short- and long-term epigenetic, transcriptional., and biochemical consequences in the rat brain

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