PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer’s disease
Sophie Schröder,
Ulrike Fuchs,
Verena Gisa
et al.
Abstract:Astrocytes provide crucial support for neurons, contributing to synaptogenesis, synaptic maintenance, and neurotransmitter recycling. Under pathological conditions, deregulation of astrocytes contributes to neurodegenerative diseases such as Alzheimer’s disease (AD). While most research in this field has focused on protein-coding genes, non-coding RNAs, particularly long non-coding RNAs (lncRNAs), have emerged as significant regulatory molecules. In this study, we identified the lncRNA PRDM16-DT as highly enri… Show more
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