PRC1.6 localizes on chromatin with the human silencing hub (HUSH) complex for promoter-specific silencing
Tomás C. Rodríguez,
Leonid Yurkovetskiy,
Karthika Nagalekshmi
et al.
Abstract:An obligate step in the life cycle of HIV-1 and other retroviruses is the establishment of the provirus in target cell chromosomes. Transcriptional regulation of proviruses is complex, and understanding the mechanisms underlying this regulation has ramifications for fundamental biology, human health, and gene therapy implementation. The three core components of the Human Silencing Hub (HUSH) complex, TASOR, MPHOSPH8 (MPP8), and PPHLN1 (Periphilin 1), were identified in forward genetic screens for host genes th… Show more
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