Pravastatin modulates early diabetic nephropathy in an experimental model of diabetic renal disease

Casey, Rowan G.; Joyce, Michael; Roche-Nagle, Graham; Chen, G.; Bouchier‐Hayes, David

doi:10.1016/j.jss.2004.08.001

Cited by 36 publications

(29 citation statements)

References 37 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…injection of STZ in SHR rats produced a consistent model of experimental diabetic nephropathy. It is widely accepted that there is a considerable increase in GFR in the early stage of diabetes, 28,29 and a comparable hyperfiltration, reflected by the increased creatinine clearance, was found in this study. Many factors, including hyperglycemia, prostanoids, nitrogen oxide, atrial natriuretic factor, growth hormone, glucagon, insulin, angiotensin II (ANG II), and others, have been considered as potential agents causing hyperperfusion and hyperfiltration.…”

Section: Discussionsupporting

confidence: 85%

Exogenous Hydrogen Sulfide (H₂S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats

et al. 2012

View full text Add to dashboard Cite

The coexistence of hypertension and diabetes results in the rapid development of nephropathy. Hydrogen sulfide (H 2 S) is claimed to control the vascular and renal functions. This study tested the hypothesis that exogenous H 2 S lowers the blood pressure and decreases the progression of nephropathy in spontaneously hypertensive rats (SHR) that were diabetic. Eighteen SHR were divided into three groups: SHR, SHR diabetic, and SHR diabetic treated with a group of Wistar-Kyoto rats serving as normotensive nondiabetic control. Diabetes was induced with streptozotocin (STZ) in two groups and one diabetic group received sodium hydrosulfide (NaHS), a H 2 S donor for 5 weeks. Blood pressure was measured in conscious and anesthetized states and renal cortical blood perfusion in acute studies. Plasma and urinary H 2 S levels, creatinine concentrations, and electrolytes were measured on three different occasions throughout the 35-day period. Diabetic SHR had higher blood pressure, lower plasma and urinary H 2 S levels, and renal dysfunction as evidenced by increased plasma creatinine, creatinine clearance, and decreased urinary sodium-to-potassium ratio and renal cortical blood perfusion. NaHS reduced blood pressure, increased H 2 S levels in plasma and urinary excretion, and reversed the STZ-induced renal dysfunction. The findings of this study suggest that the administration of exogenous H 2 S lowers the blood pressure and confers protection against the progression of STZ-induced nephropathy in SHR.

show abstract

Section: Discussionsupporting

confidence: 85%

Exogenous Hydrogen Sulfide (H₂S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Interestingly, the present study has also demonstrated increased plasma creatinine and creatinine clearance in diabetic groups of rats. The increased in plasma creatinine with the onset of diabetes observed in present study is in accord with a number of earlier reports 31,32 .…”

Section: Discussionsupporting

confidence: 94%

“…As far as, the glomerular filtration rate (GFR) is concern its regulation is not well understood, however it is widely accepted that there is considerable increase in the early stage of diabetes 32 . Moreover increased creatinine clearance is a risk factor and one of the earliest sign in the development of diabetic nephropathy 33 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2012

IJPSR

View full text Add to dashboard Cite

Nephropathy is one of the most common microvascular complications of diabetes. Hydrogen sulfide (H 2 S) has been implicated in controlling the renal glomerular (vascular) and tubular functions. This study investigates the metabolism of H 2 S and its effect on the progression of diabetic nephropathy. Diabetes was induced in WKY rats by streptozotocin in two groups. One diabetic group received NaHS, a H 2 S donor. While a vehicle treated group served as a control. Blood pressure was measured in conscious rats and at the end of the treatment period in anesthetized rats. In addition, pulse wave velocity (PWV) was also observed. Plasma and urine H 2 S levels and creatinine concentration and electrolytes were measured weekly throughout the 34-day period. Diabetic rats had lower (p<0.05) plasma and urine levels of H 2 S and lower urinary sodium to potassium ratio. Moreover, diabetic group had higher plasma sodium, higher absolute urinary sodium excretion, higher plasma creatinine and higher PWV (all p<0.05) but with similar mean arterial pressure compared to control (p>0.05). Treatment with the H 2 S donor restored H 2 S, plasma creatinine, plasma sodium and urinary sodium to potassium ratio significantly in diabetic-NaHS treated group and also reduced the PWV (all p<0.05). Moreover, the treated diabetic group had higher (p<0.05) creatinine clearance compared to diabetic group. The results suggested that exogenously administered H 2 S improves the renal excretory functions and vascular endothelium impairment in experimental diabetes in rats.

show abstract

“…Results of this study have shown that CA attenuated the cachectic condition along with polydipsia, polyuria and polyphagia which were commonly observed in diabetic nephropathy (Kawanishi et al, 1994;Casey et al, 2005).…”

Section: Discussionmentioning

confidence: 62%

Chebulic acid attenuates ischemia reperfusion induced biochemical alteration in diabetic rats

Silawat

Gupta

2012

Pharmaceutical Biology

View full text Add to dashboard Cite

Pravastatin modulates early diabetic nephropathy in an experimental model of diabetic renal disease

Cited by 36 publications

References 37 publications

Exogenous Hydrogen Sulfide (H₂S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats

Exogenous Hydrogen Sulfide (H₂S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats

Untitled

Chebulic acid attenuates ischemia reperfusion induced biochemical alteration in diabetic rats

Contact Info

Product

Resources

About

Pravastatin modulates early diabetic nephropathy in an experimental model of diabetic renal disease

Cited by 36 publications

References 37 publications

Exogenous Hydrogen Sulfide (H2S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats

Exogenous Hydrogen Sulfide (H2S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats

Untitled

Chebulic acid attenuates ischemia reperfusion induced biochemical alteration in diabetic rats

Contact Info

Product

Resources

About

Exogenous Hydrogen Sulfide (H₂S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats

Exogenous Hydrogen Sulfide (H₂S) Reduces Blood Pressure and Prevents the Progression of Diabetic Nephropathy in Spontaneously Hypertensive Rats