Praseodymium trivalent ion is an effective inhibitor of mitochondrial basic amino acids and carnitine/acylcarnitine carriers

Incampo, Giovanna; Giangregorio, Nicola; Gambacorta, Nicola; Nicolotti, Orazio; Pacifico, Concetta; Palmieri, Luigi; Tonazzi, Annamaria

doi:10.1016/j.bbabio.2022.148557

Biochimica et Biophysica Acta (BBA) - Bioenergetics

2022

DOI: 10.1016/j.bbabio.2022.148557

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Praseodymium trivalent ion is an effective inhibitor of mitochondrial basic amino acids and carnitine/acylcarnitine carriers

Giovanna Incampo¹,

Nicola Giangregorio²,

Nicola Gambacorta³

et al.

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2023

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SLC25 family with energy metabolism and immunity in malignant tumors

Zhang,

Wang,

et al. 2023

Oncologie

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Solute Carrier Family 25 (SLC25) is the largest family of mitochondrial membrane proteins in the human body, consisting of 53 members. Mitochondrial phosphate carriers (MPiC), cellular iron metabolism, voltage-dependent anion channels (VDAC), and oxidative phosphorylation in the SLC25 family play dominant roles in material transport, energy metabolism, etc. SLC25 family-related proteins are involved in the regulation of the progression of a variety of cancers, including colon, gastric, and lung cancers. In addition, the SLC25 family has been implicated in endoplasmic reticulum stress (ERS) and immunity. Since SLC25 family proteins are involved in cancer progression and are associated with endoplasmic reticulum stress and immunity, exploring inhibitors of SLC25 family-related proteins is essential. However, the exact mechanism of SLC25 family-related proteins involved in cancer, as well as potential targets and SLC25 inhibitors have not been reported in the literature. This article focuses on summarizing the relevance of the SLC25 family to cancer, ERS, and immunity. This review also provides a comprehensive overview of SLC25 family-related inhibitors.

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SLC25 family with energy metabolism and immunity in malignant tumors

Zhang,

Wang,

et al. 2023

Oncologie

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Praseodymium trivalent ion is an effective inhibitor of mitochondrial basic amino acids and carnitine/acylcarnitine carriers

Cited by 1 publication

References 44 publications

SLC25 family with energy metabolism and immunity in malignant tumors

SLC25 family with energy metabolism and immunity in malignant tumors

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