Pranlukast Inhibits Exercise-Induced Bronchospasm in Asthmatic Children: A Randomized, Multicenter, Double-Blind, Placebo-Controlled Two-Period Crossover Trial

Nishima, Sankei; Furusho, Kenshi; Morikawa, Akihiro; Mochizuki, Hiroyuki; Akasaka, Toru; Sugimoto, Hideo; Ikebe, Toshiichi; Nishimuta, Toshiyuki; Sekine, Kunio; Yamada, Masanori; Odajima, Hiroshi; Motomura, Chikako; Yamatodani, Atsushi

doi:10.1089/pai.2005.18.5

Cited by 4 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pranlukast dry syrup inhibited exercise-induced bronchospasm in children with asthma in a randomized, multicenter, double-blind, placebo-controlled, two-period crossover trial. 35 Patients were 17 children of mean age 11.0 (7)(8)(9)(10)(11)(12)(13)(14) years with stable asthma and a history of typical symptoms of exercise-induced bronchospasm. Pranlukast dry syrup or a placebo was administered after dinner on the first day and after breakfast on the second day for each period of the study.…”

Section: Randomized Controlled Trial Of Exercise-induced Bronchospasmmentioning

confidence: 99%

Pranlukast hydrate in the treatment of pediatric bronchial asthma

Yoshihara¹

2013

PHMT

View full text Add to dashboard Cite

Pranlukast hydrate is a potent, selective, orally active, cysteinyl leukotriene antagonist that binds at the type 1 receptor. It is used as a 10% dry syrup to treat asthma and allergic rhinitis in pediatric patients. In a 4-week, dose-finding study, a dose-dependent improvement in lung function was observed in pediatric patients with asthma at an optimal dose of 5.1-10 mg/kg/ day. In a comparative, randomized, double-blind, 4-week multicenter trial, pranlukast dry syrup 7 mg/kg/day achieved significantly better final overall improvement (71.4%) versus oxatomide 1 mg/kg/day (37.2%) in pediatric patients older than one year with asthma. In two 12-week, open-label trials and in a long-term open-label trial of treatment for up to 24 months, pranlukast dry syrup improved asthma control over baseline values. In a prospective post-marketing surveillance study and a long-term follow-up study, the safety and efficacy of pranlukast dry syrup was confirmed in infants younger than one year with bronchial asthma. In a 4-week, open-label trial, pranlukast dry syrup improved overall health-related quality of life and physical and emotional domain scores over baseline in pediatric patients with asthma. In a randomized, multicenter, double-blind, placebo-controlled, two-period crossover trial, pranlukast dry syrup significantly inhibited exercise-induced bronchospasm in children with asthma compared with placebo. In a modified Childhood Asthma Control Test, pranlukast dry syrup was significantly more effective in controlling asthma in patients younger than 4 years with the common cold. These findings show that pranlukast is useful and beneficial for treating pediatric patients with bronchial asthma.

show abstract

Section: Randomized Controlled Trial Of Exercise-induced Bronchospasmmentioning

confidence: 99%

Pranlukast hydrate in the treatment of pediatric bronchial asthma

Yoshihara¹

2013

PHMT

View full text Add to dashboard Cite

show abstract

“…As both diseases affect the airways and exacerbation of nasal symptoms influences asthma symptoms, these two diseases are increasingly viewed from the perspective of the 'one airway, one disease' paradigm (6). Pranlukast dry syrup is an LTRA that is used as a monotherapy for bronchial asthma or AR (7)(8)(9)(10); however, its use in children with both diseases has not been examined.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a leukotriene receptor antagonist for pediatric cedar pollen allergy complicated by asthma

Yoshihara

Kikuchi

Saitou

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Leukotriene receptor antagonists (LTRAs) are identified as a monotherapy for asthma and allergic rhinitis; however, their use in children for treatment of these diseases has not been examined. Accordingly, the present study investigated the efficacy of pranlukast dry syrup for children with both pollinosis and asthma. The subjects were children receiving treatment for asthma who were also diagnosed with cedar pollen allergy. Patients were divided into a group that received continuous treatment with pranlukast (group A; n=20) and a group that commenced add-on treatment for pollinosis following the onset of symptoms (group B; n=20). Patients in group B were randomly allocated to subgroup B1 (add-on treatment with pranlukast dry syrup) or subgroup B2 (add-on treatment with a second-generation antihistamine). In both groups, nasal and ocular symptoms were evaluated every day and recorded in a diary. Exacerbation of nasal obstruction was demonstrated in group B; however, not in group A. There was a significant difference in symptoms observed between the two groups during the late peak pollen period (P<0.05). The incidence of nasal obstruction (defined as a nasal obstruction score ≥3 or use of a nasal steroid spray) was significantly lower in group A compared with group B (P<0.05). The maximum scores for sneezing and nasal obstruction during the late peak of the pollen season were lowest in group A, followed by subgroup B1 and subgroup B2. The present study demonstrated that long-term administration of LTRA for the management of asthma may improve nasal symptoms of pollinosis during the pollen season in children with pollinosis and asthma.

show abstract

Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma in adults and children

Chauhan

Ducharme

2012

Cochrane Database of Systematic Reviews

185

107

View full text Add to dashboard Cite

Background Anti-leukotrienes (5-lipoxygenase inhibitors and leukotriene receptors antagonists) serve as alternative monotherapy to inhaled corticosteroids (ICS) in the management of recurrent and/or chronic asthma in adults and children. Objectives To determine the safety and efficacy of anti-leukotrienes compared to inhaled corticosteroids as monotherapy in adults and children with asthma and to provide better insight into the influence of patient and treatment characteristics on the magnitude of effects. Search methods We searched MEDLINE (1966 to Dec 2010), EMBASE (1980 to Dec 2010), CINAHL (1982 to Dec 2010), the Cochrane Airways Group trials register, and the Cochrane Central Register of Controlled Trials (Dec 2010), abstract books, and reference lists of review articles and trials. We contacted colleagues and the international headquarters of anti-leukotrienes producers. Selection criteria We included randomised trials that compared anti-leukotrienes with inhaled corticosteroids as monotherapy for a minimum period of four weeks in patients with asthma aged two years and older. Data collection and analysis Two review authors independently assessed the methodological quality of trials and extracted data. The primary outcome was the number of patients with at least one exacerbation requiring systemic corticosteroids. Secondary outcomes included patients with at least one exacerbation requiring hospital admission, lung function tests, indices of chronic asthma control, adverse effects, withdrawal rates and biological inflammatory markers. Main results Sixty-five trials met the inclusion criteria for this review. Fifty-six trials (19 paediatric trials) contributed data (representing total of 10,005 adults and 3,333 children); 21 trials were of high methodological quality; 44 were published in full-text. All trials pertained to patients with mild or moderate persistent asthma. Trial durations varied from four to 52 weeks. The median dose of inhaled corticosteroids was quite homogeneous at 200 μg/day of microfine hydrofluoroalkane-propelled beclomethasone or equivalent (HFABDP eq). Patients treated with anti-leukotrienes were more likely to suffer an exacerbation requiring systemic corticosteroids (N = 6077 participants; risk ratio (RR) 1.51, 95% confidence interval (CI) 1.17, 1.96). For every 28 (95% CI 15 to 82) patients treated with anti-leukotrienes instead of inhaled corticosteroids, there was one additional patient with an exacerbation requiring rescue systemic corticosteroids. The magnitude of effect was significantly greater in patients with moderate compared with those with mild airway obstruction (RR 2.03, 95% CI 1.41, 2.91 versus RR 1.25, 95% CI 0.97, 1.61), but was not significantly influenced by age group (children representing 23% of the weight versus adults), anti-leukotriene used, duration of intervention, methodological quality, and funding source. Significant group differences favouring inhaled corticosteroids were noted in most secondary outcomes including patients with at least one e...

show abstract

Pranlukast Inhibits Exercise-Induced Bronchospasm in Asthmatic Children: A Randomized, Multicenter, Double-Blind, Placebo-Controlled Two-Period Crossover Trial

Cited by 4 publications

References 19 publications

Pranlukast hydrate in the treatment of pediatric bronchial asthma

Pranlukast hydrate in the treatment of pediatric bronchial asthma

Efficacy of a leukotriene receptor antagonist for pediatric cedar pollen allergy complicated by asthma

Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma in adults and children

Contact Info

Product

Resources

About