“…Although uncommon, adverse events such as nausea, dizziness, headache, sleep disorders (insomnia, somnolence, sudden onset of sleep), and psychiatric reactions (mainly hallucinations) might occur, mainly in association with dose escalation [9, 11]. There is limited information on pramipexole overdose [14, 15], but, since tolerance appears rapidly, slow titration is indicated [9]. In HD patients with uremic RLS, treatment with lower doses of pramipexole (0.125 – 0.5 mg/d) was effective, with no major adverse event [7].…”