Pralidoxime mesylate absorption and heart rate response to atropine sulphate following intramuscular administration of solution mixtures.

Abstract

1The oxime pralidoxime mesylate (P2S) and atropine sulphate, alone and mixed, have been administered intramuscularly to forty-four human subjects. Doses of 750 mg and 500 mg P2S and 2.0 mg atropine sulphate were used. 2 The presence of P2S had no significant influence, as judged by effect on heart rate, on the absorption of atropine although there was a tendency for atropine to exert its effects more rapidly when administered mixed with P2S. 3 No significant difference in the rate of uptake of P2S as judged by plasma levels following injection, between a combined (plus atropine) and single (P2S alone) intramuscular injection was found.

Pharmacokinetics of the Oxime HI‐6 from a Mixture with Atropine Sulphate in Dogs

“…The resorption of atropine from such a combination in man has been reported to be slightly affected (Holland & White 1971;Martin 1973;Sidell 1974) or markedly delayed in the presence of the oxime (Sidell et al 1970;Fried1 et al 1989). By contrast, kinetic profiles of monopyridinium oximes, pralidoxime methanesulphonate and pralidoxime chloride, seemed not to be significantly altered by the presence of various cholinolytics both in animals and humans (Vojvodii: & Maksimovii: 1972;Holland et al 1975;Amitai et al 1987).…”