Präklinische Bildgebung im Tiermodell bei Strahlentherapie

Nikolaou, Konstantin; Cyran, Clemens C.; Lauber, Kirsten; Reiser, Maximilian; Clevert, D.‐A.

doi:10.1007/s00117-011-2194-y

Cited by 5 publications

(2 citation statements)

References 68 publications

(61 reference statements)

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“…Ein Schwerpunkt der Ultraschallforschung liegt aktuell im Bereich der CEUS und quantitativen Elastografie (Strain-oder Scherwellenelastografie) und zukünftig auch der molekularen Bildgebung [22,23]. Durch die Zusammenarbeit innerhalb von interdisziplinären Ultraschallzentren können interdisziplinäre und tierexperimentelle Forschungsvorhaben umgesetzt werden [23,24]. Der Aufbau einer fachübergreifenden Bilddatenbank anhand standardisierter, vereinheitlichter US-Protokolle kann die Forschungsaktivität sowohl innerklinisch als auch national deutlich verbessern.…”

Section: Forschungunclassified

“…A current focus of ultrasound research is CEUS and quantitative elastography (strain or shear wave elastography) and in the future also molecular imaging [22,23]. As a result of collaboration within interdisciplinary ultrasound centers, interdisciplinary research and animal experiments can be conducted [23,24]. The creation of an interdisciplinary image database based on standardized US protocols can significantly improve research both internally as well as nationally.…”

Section: Researchmentioning

confidence: 99%

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Concepts in the Establishment of Interdisciplinary Ultrasound Centers: The Role of Radiology

Clevert

Jung

Weber

et al. 2022

Rofo

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Background Ultrasound (US) is widely used as a fast and cost-efficient first-choice imaging technique without relevant side effects for a variety of diagnostic tasks. Due to technical advances, more complex and sophisticated methods such as color-coded duplex ultrasound, image fusion, contrast-enhanced ultrasound (CEUS), and ultrasound-guided interventions have become increasingly important in diagnostic algorithms. Method This study presents an overview of all aspects regarding the establishing of an interdisciplinary US center based on five representative examples in Germany. These aspects include topics of ultrasound education, research, economics, and administration. Results The goal of an interdisciplinary US center is to bundle the use of equipment, staff, rooms, and infrastructure resources (optimization of equipment availability and use of new techniques) to expand the range of examinations, to promote resident training, and to boost continuing medical education of residents. This should result in better patient care and has additionally improved patient care while considering the added value for the participating institutions involved. Interdisciplinary US centers allow a reduction of the number of US devices needed in a hospital and more efficient use of available equipment through bedside time optimization by central organization within interdisciplinary management. The focused application of special US techniques such as CEUS or image fusion for complex, difficult interventions as well as the training and education of younger colleagues in using these techniques is centrally organized by experts and can be improved through the multidisciplinary experience available. Conclusion Organizational structures, sharing of materials, and standardization of diagnostic reports facilitate and accelerate cooperation with the referring specialty. Key Points: Citation Format

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Section: Forschungunclassified

Section: Researchmentioning

confidence: 99%

Concepts in the Establishment of Interdisciplinary Ultrasound Centers: The Role of Radiology

Clevert

Jung

Weber

et al. 2022

Rofo

View full text Add to dashboard Cite

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Sonographische Diagnostik diffuser Lebererkrankungen

et al. 2012

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Correlation of Perfusion MRI and 18F-FDG PET Imaging Biomarkers for Monitoring Regorafenib Therapy in Experimental Colon Carcinomas with Immunohistochemical Validation

et al. 2015

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ObjectivesTo investigate a multimodal, multiparametric perfusion MRI / 18F-fluoro-deoxyglucose-(18F-FDG)-PET imaging protocol for monitoring regorafenib therapy effects on experimental colorectal adenocarcinomas in rats with immunohistochemical validation.Materials and MethodsHuman colorectal adenocarcinoma xenografts (HT-29) were implanted subcutaneously in n = 17 (n = 10 therapy group; n = 7 control group) female athymic nude rats (Hsd:RH-Foxn1rnu). Animals were imaged at baseline and after a one-week daily treatment protocol with regorafenib (10 mg/kg bodyweight) using a multimodal, multiparametric perfusion MRI/18F-FDG-PET imaging protocol. In perfusion MRI, quantitative parameters of plasma flow (PF, mL/100 mL/min), plasma volume (PV, %) and endothelial permeability-surface area product (PS, mL/100 mL/min) were calculated. In 18F-FDG-PET, tumor-to-background-ratio (TTB) was calculated. Perfusion MRI parameters were correlated with TTB and immunohistochemical assessments of tumor microvascular density (CD-31) and cell proliferation (Ki-67).ResultsRegorafenib significantly (p<0.01) suppressed PF (81.1±7.5 to 50.6±16.0 mL/100mL/min), PV (12.1±3.6 to 7.5±1.6%) and PS (13.6±3.2 to 7.9±2.3 mL/100mL/min) as well as TTB (3.4±0.6 to 1.9±1.1) between baseline and day 7. Immunohistochemistry revealed significantly (p<0.03) lower tumor microvascular density (CD-31, 7.0±2.4 vs. 16.1±5.9) and tumor cell proliferation (Ki-67, 434.0 ± 62.9 vs. 663.0 ± 98.3) in the therapy group. Perfusion MRI parameters ΔPF, ΔPV and ΔPS showed strong and significant (r = 0.67-0.78; p<0.01) correlations to the PET parameter ΔTTB and significant correlations (r = 0.57-0.67; p<0.03) to immunohistochemical Ki-67 as well as to CD-31-stainings (r = 0.49-0.55; p<0.05).ConclusionsA multimodal, multiparametric perfusion MRI/PET imaging protocol allowed for non-invasive monitoring of regorafenib therapy effects on experimental colorectal adenocarcinomas in vivo with significant correlations between perfusion MRI parameters and 18F-FDG-PET validated by immunohistochemistry.

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Präklinische Bildgebung im Tiermodell bei Strahlentherapie

Cited by 5 publications

References 68 publications

Concepts in the Establishment of Interdisciplinary Ultrasound Centers: The Role of Radiology

Concepts in the Establishment of Interdisciplinary Ultrasound Centers: The Role of Radiology

Sonographische Diagnostik diffuser Lebererkrankungen

Correlation of Perfusion MRI and 18F-FDG PET Imaging Biomarkers for Monitoring Regorafenib Therapy in Experimental Colon Carcinomas with Immunohistochemical Validation

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