Pragmatic language dysfunction in systemic lupus erythematosus patients: Results from a single center Italian study

Ceccarelli, Fulvia; Pirone, Carmelo; Mina, Concetta; Mascolo, Alfredo Paolo; Perricone, Carlo; Massaro, Laura; Alessandri, Cristiano; Valesini, Guido; Conti, Fabrizio

doi:10.1371/journal.pone.0224437

Cited by 3 publications

(4 citation statements)

References 36 publications

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“…SLICC was also associated with cognitive impairment, but only the impairment of neurological domain of the used evaluation tool was independently associated. The association of cognitive impairment with cumulative damage was found by others, [39][40][41] and it is comprehensible that permanent structural damage of the nervous system impairs its functioning.…”

Section: Discussionmentioning

confidence: 84%

“…The MMSE also identified language as another cognitive domain that was weak in this population. Ceccarelli et al 22 found that difficulties associated with pragmatic language were present in more than 50% of their sample. This study suggests that other language components, such as naming, repetition, comprehension, reading, writing, and visual constructive ability, which are evaluated by the MMSE, 13 may also be present.…”

Section: Discussionmentioning

confidence: 93%

“…40 However, the study of this association has yield contradictory results. While anticardiolipin antibodies have been positively linked to cognitive deterioration in adults with SLE 41 and in normal elderly individuals, 42 others could not prove this association. Hanly et al, 7 who have used dynamic contrast-enhanced MRI scanning, found that cognitive impairment in SLE was associated with blood–brain barrier leakage independently of the circulating autoantibody profile (including antiphospholipid).…”

Section: Discussionmentioning

confidence: 98%

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Cognitive dysfunction in patients with systemic lupus erythematosus. A cross-sectional study in a Brazilian sample

Borba

Dias

Vanzin

et al. 2023

Lupus

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Background Cognitive dysfunction (CD) is frequently found in patients with systemic lupus erythematosus (SLE) and contributes to impairment in the patient’s quality of life. Aim To study CD in a sample of patients and the possible associations with cumulative damage, disease activity, clinical/serological profile, and cumulative glucocorticoid dose. Methods Included in this study are 103 patients with SLE and 95 controls for cognitive performance through MoCA (Montreal Cognitive Assessment) and MMSE (Mini-Mental State Examination). Disease activity was measured by SLEDAI (Systemic Lupus Erythematosus Disease Activity Index) and cumulative organ damage by SLICC/ACR/DI (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index). CES-D (Center for Epidemiological Studies-Depression) scale was used to evaluate depression. Data on clinical and serological profile, treatment, and cumulative glucocorticoid dose were also collected. Results Patients with SLE had worse performance in the MoCA ( p = 0.009) and MMSE ( p = 0.01) than controls. The MoCA results showed that visuospatial and abstraction domains ( p = 0.03 and p = 0.002, respectively) were impaired, and the MMSE results showed that language and spatial orientation were reduced ( p = 0.002 and p = 0.01, respectively) when compared to controls. Both questionnaires (MoCA with r = −0.29 and MMSE r = −0.21) correlated negatively with SLICC/ACR/DI and the MoCA with SLEDAI (r = −0.22). No associations were found with cumulative glucocorticoid dose, degree of depression, and clinical or serological profile. Conclusions According to the MoCA, visuospatial cognition and abstraction were impaired, and according to the MMSE, spatial orientation and language were impaired in patients with SLE. The CD was correlated with cumulative damage and disease activity. These findings demonstrate that both disease-activity and disease-injury associated CD is found broadly in SLE patients in a Brazilian population, supporting the prior reports of CD in other regional SLE populations.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 98%

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Cognitive dysfunction in patients with systemic lupus erythematosus. A cross-sectional study in a Brazilian sample

Borba

Dias

Vanzin

et al. 2023

Lupus

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“…6 Furthermore, data from the Sapienza Lupus Cohort identified also the impairment of pragmatic language in SLE patients. 7 The involvement of the fronto-subcortical circuit, the complex DMN network, the development and control of executive functions network and amygdala-hippocampal connections 8 suggested the evaluation of other unexplored fields of research in SLE patients, the so-called emotional intelligence, understood as the ability to reason with emotions to facilitate thinking, and the application of Visual Thinking Strategies Method (VTS). Thus, the present case-control study aims to evaluate emotional intelligence in a monocentric Italian SLE cohort compared to healthy control; secondly, we applied the VTS method in a subgroup of patients, highlighting the possible impact of art in the improvement of cognitive skills, such as critical thinking and problem solving, and quotient and scores obtained in the different areas of emotional intelligence.…”

Section: Introductionmentioning

confidence: 99%

Science and visual Arts: Binomial or Dichotomy? A Pilot study in Systemic Lupus Erythematosus patients

Ferrara

Perrone

Mina

et al. 2022

Lupus

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Scientific literature demonstrated the impairment in cognitive/executive functions and pragmatic language in SLE patients, potentially involving also asymptomatic subjects. The present study focuses on the assessment in an SLE cohort of emotional intelligence, which is an ability regulated by the network of the executive functions, cognitive abilities involved in the initiation, planning, organization, and regulation of achievement-oriented behaviors: with emotional. Thus, emotional intelligence, defined as the ability to reason with emotions, was evaluated in a SLE cohort diagnosed according to the 1997 American College of Rheumatology criteria. As control healthy subjects were enrolled. The Mayer–Salovey–Caruso Emotional Intelligence Test (MSCEIT), a skill-scale that measures the ability to perform tasks and solve emotional problems, was administered to patients and controls. Second, a group of SLE patients underwent the Visual Thinking Strategies (VTS) method in order to assess the potential impact of art in cognitive skills like critical thinking, problem solving, and emotional intelligence quotient. The protocol also included the evaluation of the improvement of some skills using a validated VTS skill grid. Self-reported scales for anxiety and depression were performed to rule out the influence of mood disorders on emotional intelligence. The present study demonstrated similar quotient scores of emotional intelligence in SLE patients and healthy controls. Furthermore, VTS method could help in improving this cognitive ability in patients, by implementing critical thinking and problem solving, promoting empathy, and improving tolerance to ambiguity and relational capacity.

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Quantitative MRI adds to neuropsychiatric lupus diagnostics

et al. 2020

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Objective Attributing neuropsychiatric manifestations to SLE is often challenging. Brain white matter lesions are frequent in SLE at MRI, but their diagnostic role is unclear. Here, we assessed whether white matter lesions count, volume and distribution measurement can help in the diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE). Methods Brain dual-echo and 3D T1-weighted sequences were acquired from 32 patients with SLE and 32 healthy controls with a 3 T-scanner and employed to derive T2-hyperintense lesion volume (T2LV), number (T2LN) and probability maps (LPM) using a semi-automatic local thresholding segmentation technique. NPSLE was classified as per the ACR nomenclature, the Italian Society for Rheumatology algorithm and by clinical impression. Clinical descriptors including the SLE International Collaborating Clinics/ACR damage index (SDI) were also recorded. Results Higher T2LV were observed in SLE vs healthy controls (P < 0.001) and in NPSLE vs other SLE (P =0.006). Patients with NPSLE also had higher T2LN (P =0.003) compared with other SLE. In SLE, T2LPM revealed a high prevalence of lesions in the splenium of the corpus callosum, right superior longitudinal fasciculus and right corona radiata. T2LV and T2LN correlated with SLE duration (rho = 0.606; P <0.001 and rho = 0.483; P =0.005, respectively) and age (rho = 0.478; P =0.006 and rho = 0.362; P = 0.042, respectively). T2LV also correlated with SDI (rho = 0.352; P =0.048). SLE patients with fatigue had lower T2LN (P =0.038) compared with patients without fatigue. Thresholds of T2LV ≥ 0.423 cm3 or of T2LN ≥ 12 were associated with definite NPSLE and improved the classification of patients with possible NPSLE per clinical impression. Conclusion Brain white matter lesions (WML) quantitation adds to NPSLE diagnostics.

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Pragmatic language dysfunction in systemic lupus erythematosus patients: Results from a single center Italian study

Cited by 3 publications

References 36 publications

Cognitive dysfunction in patients with systemic lupus erythematosus. A cross-sectional study in a Brazilian sample

Cognitive dysfunction in patients with systemic lupus erythematosus. A cross-sectional study in a Brazilian sample

Science and visual Arts: Binomial or Dichotomy? A Pilot study in Systemic Lupus Erythematosus patients

Quantitative MRI adds to neuropsychiatric lupus diagnostics

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