Pragmatic Decisions Over Nonsteroidal Antiinflammatory Drug Treatment in Osteoarthritis — Continuous Versus Intermittent: Figure 1.

Penetration of topical diclofenac sodium 4 % spray gel into the synovial tissue and synovial fluid of the knee: a randomised clinical trial

“…The concentration of diclofenac in synovial fluid is similar to that in plasma, as described recently by Miyatake et al [18]. An explanation may be that synovial fluid concentrations reflect plasma concentrations because this is a highly vascularised compartment [19]. The concentrations that were observed in the synovial fluid are in accordance with those reported by Arcangeli et al [1].…”