Prader-Willi syndrome: a nest for premature coronary artery disease?

Bras, D; Semedo, Pedro; Picarra, B; Fernandes, Renato

doi:10.1136/bcr-2017-222828

Cited by 6 publications

(1 citation statement)

References 18 publications

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“…One case report detailed a 27-year-old man with PWS and multiple underlying comorbidities such as obesity, hypertension, diabetes mellitus, and dyslipidemia, which led to three-vessel coronary artery disease (CAD) [7]. These findings emphasize how patients with PWS are at greater risk of early-onset heart disease, stressing the urgent need for more specific strategies to manage cardiovascular risks.…”

Section: Discussionmentioning

confidence: 99%

Complex Cardiovascular Morbidities in Prader-Willi Syndrome: A Multidisciplinary Approach

Alba,

Omidvarnia,

Bies

et al. 2024

Cureus

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This case emphasizes the complexity of Prader-Willi syndrome (PWS), the need for a collaborative approach from specialists, and a closer look at the various cardiovascular complexities associated with this syndrome. While current treatments focus on managing symptoms, ongoing genetic research offers hope for more favorable outcomes. Further studies are crucial to gauge the effectiveness of these treatments for PWS patients. We detail a patient with a complex medical history of PWS, further complicated by congenital heart disease with Eisenmenger's syndrome, diabetes mellitus, pulmonary hypertension, venous insufficiency, hypothyroidism, and hyperlipidemia. Reported in this study is a compilation of clinical data as well as suggestions from several medical specialists in applying a multifaceted approach to treatment, significantly emphasizing the need for interdisciplinary care and management of patients experiencing a combination of various medical issues with an emphasis on cardiovascular complications.

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Section: Discussionmentioning

confidence: 99%

Complex Cardiovascular Morbidities in Prader-Willi Syndrome: A Multidisciplinary Approach

Alba,

Omidvarnia,

Bies

et al. 2024

Cureus

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The consequences of hyperphagia in people with Prader-Willi Syndrome: A systematic review of studies of morbidity and mortality

Bellis

Kuhn

Adams

et al. 2022

European Journal of Medical Genetics

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Male hypogonadotropic hypogonadism in various genetic disorders

Niedobylski

Laszczak

Warchoł

et al. 2020

J Educ Health Sport

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Introduction and purpose: Male hypogonadism is diagnosed in patients with total testosterone under 9-12nmol/L (250-350ng/dl) in serum which is associated with numerous symptoms which can severely lower the quality of patients life. Due to the cause and associated levels of gonadotropins it can be divided to hypergonadotropic and hypogonadotropic hypogonadism. Hypogonadotropic hypogonadism occurs far less often, but it’s considered to remain underdiagnosed. The purpose of this study is to review most of the inborn diseases that involve hypogonadotropic hypogonadism as one of their components.Current state of knowledge: Patients with Kallmann syndrome constitute the majority of confirmed hypogonadotropic hypogonadism cases, however due to variable epidemiological data and differing diagnosing processes the exact incidence cannot be estimated – it ranges from 1 in 85 000, to 1 in 5000 males and about 3-4 times less often in women. Other conditions that can occur with hypogonadotropic hypogonadism are Isolated Gonadotropin-Releasing Hormone deficiency, Gonadotropin disorders, Prader-Willi Syndrome, some pleiotropic syndromes like CHARGE syndrome, Patau syndrome, Pfeiffer syndrome, Hartsfield syndrome, Waardenburg syndrome, Bardet-Biedl syndrome, or other syndromes. The evaluation and treatment of some of these conditions does not involve hypogonadism or other gonadal disorders due to short lifespan, which cause the underestimations in hypogonadism morbidity.Conclusions: Regardless of lower incidence of hypogonadotropic hypogonadism compared to hypergonadotropic type, endocrinologists should stay aware of its under-diagnosis and actively search for signs of low gonadotropic hormones and gonadotropin-releasing hormone levels in hypogonadal patients.

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Prader-Willi syndrome: a nest for premature coronary artery disease?

Cited by 6 publications

References 18 publications

Complex Cardiovascular Morbidities in Prader-Willi Syndrome: A Multidisciplinary Approach

Complex Cardiovascular Morbidities in Prader-Willi Syndrome: A Multidisciplinary Approach

The consequences of hyperphagia in people with Prader-Willi Syndrome: A systematic review of studies of morbidity and mortality

Male hypogonadotropic hypogonadism in various genetic disorders

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