Practolol (Eraldin) eye drops as an ocular hypotensive agent.

Vale, Janet; Phillips, C I

doi:10.1136/bjo.57.3.210

Cited by 44 publications

(21 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This conclusion is supported because Wettrell and Pandolfi (I975) found no significant difference in the ocular hypotensive effect on normal eyes of these two drugs which they gave in the above doses twice daily for eight days. This conclusion was predictable from the much greater efficacy of racemic propranolol (that is, a mixture of the dextroand laevo-rotary form) than dextro-propranolol since the former has 6oX the 5-blocking potency of the latter but the same effect on membrane stability (Vale and Phillips, 1970).…”

Section: Discussionmentioning

confidence: 99%

Atenolol versus propranolol. A comparison of ocular hypotensive effect of an oral dose.

MacDonald¹,

Cullen²,

Phillips³

1976

British Journal of Ophthalmology

Self Cite

View full text Add to dashboard Cite

EdinburghBoth atenolol and propranolol by mouth reduce ocular tension in normal and glaucomatous eyes (Phillips, Howitt, and Rowlands, i967; Elliot, Cullen, and Phillips, 1975; Wettrell and Pandolfi, 1975). These randomly selected for examination, the blood pressure and pulse rate were measured and either 50 mg of atenolol or 40 mg of propranolol was given by mouth. The observers were unaware of which treatment was given and the order of administration was randomized. The same three properties were measured at hourly intervals for seven hours thereafter, by the same examiners. The same procedure was carried out on the second test day with cross-over of the drugs; five patients (at random) had atenolol first and propranolol second, while the other five had the drugs in the reverse order.

show abstract

Section: Discussionmentioning

confidence: 99%

Atenolol versus propranolol. A comparison of ocular hypotensive effect of an oral dose.

MacDonald¹,

Cullen²,

Phillips³

1976

British Journal of Ophthalmology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Topical practolol was effective in glaucoma patients (110,111) although side effects were evident with oral administration (111). Short-term studies of 0.5% and 1% levobunolol (112) and 0.3% to 2% levobunolol (113) showed dose dependent reductions in pressure in glaucomatous eyes without substantial side effects.…”

Section: Beta-adrenergic Drugsmentioning

confidence: 94%

A Synopsis of Recent Developments in Antiglaucoma Drugs

McLaughlin¹,

Chiou²

1985

Journal of Ocular Pharmacology and Therapeutics

View full text Add to dashboard Cite

Open-angle glaucoma is treated primarily with drugs, some of which have been used clinically for years. These drugs include: 1) cholinergic agonists that increase aqueous humor outflow, 2) adrenergic agonists and antagonist that affect both aqueous humor formation and outflow, and 3) carbonic anhydrase inhibitors that decrease aqueous humor formation.Several new classes of drugs are being tested for efficacy and mechanism of action. They include: 1) the D-isomer of timolol that reduces aqueous humor formation without producing adrenergic blockade, 2) dopaminergic agonists and antagonists, including bromocriptine and butyrophenones that reduce intraocular pressure, and 3) cannabinoids that reduce aqueous humor formation and increase outflow.In addition, several other types of drugs, such as prostaglandins, diuretics, Na+,K+-ATPase inhibitors, and adenyl cyclase stimulators are just now beginning to be studied.

show abstract

“…Other beta-blockers such as atenolol (5,6), labetalol (7), oxprenolol (8), pindolol (9), and practolol (10) have also been shown to lower IOP in patients with glaucoma.…”

Section: Introductionmentioning

confidence: 97%

Comparative Effects of SCH 19927 and Timolol on Intraocular Pressure of Conscious Rabbits and Relative Systemic Beta-blockade Resulting from Topical Administration

Watkins¹,

Cummins²,

Vliet³

et al. 1985

Journal of Ocular Pharmacology and Therapeutics

View full text Add to dashboard Cite

SCH 19927, the RR isomer of labetalol, has been shown to possess beta-blocking and vasodilator properties.It was compared to timolol for ability to lower intraocular pressure (IOP) in conscious rabbits.Its potential for systemic beta-blockade after topical administration was also assessed.Dose-related reductions in IOP followed topically applied SCH 19927 (0.1-1.0%). Timolol in concentrations less than 0.5% was not effective in lowering IOP. Timolol (0.1 and 0.5%) strongly inhibited tachycardia induced by iv isoproterenol. A 1.0% concentration of SCH 19927 was less effective than 0.5% timolol in inhibiting the isoproterenol-induced tachycardia; 0.1% SCH 19927 caused only minor inhibitory actions.Thus, not only is SCH 19927 at least as potent in lowering IOP in conscious rabbits, its topical administration results in less systemic beta-blockade than does timolol.

show abstract

Practolol (Eraldin) eye drops as an ocular hypotensive agent.

Cited by 44 publications

References 9 publications

Atenolol versus propranolol. A comparison of ocular hypotensive effect of an oral dose.

Atenolol versus propranolol. A comparison of ocular hypotensive effect of an oral dose.

A Synopsis of Recent Developments in Antiglaucoma Drugs

Comparative Effects of SCH 19927 and Timolol on Intraocular Pressure of Conscious Rabbits and Relative Systemic Beta-blockade Resulting from Topical Administration

Contact Info

Product

Resources

About