The use of "engineering controls" included the integration of NFCs into the IV access system both for needle safety and for the prevention of central-line associated bloodstream infections (CLABSI) (3-5). NFCs allow for the administration of IV fluids, medications and blood to indwelling venous or arterial catheters without the use of needles. NFCs are also used for the withdrawal of blood samples and for aspiration of blood to check the catheter for patency. While the introduction of NFCs greatly reduced the risk of needle-stick injuries for healthcare workers, their use has been associated with other complications such as an increase in catheter occlusions and CLABSIs (6-11). In response to the increase in CLABSI related to the use of NFCs, medical device companies began designing and developing lower-risk devices (12). Over the past 20 years, 4 categories of NFC designs have emerged (2, 13). While there is no regulatory body that recognizes the categories of NFC as being indicative of function or performance (13), NFCs are typically marketed as being "positive", "negative", "neutral" (6, 12-16) or pressure-activated anti-reflux (9, 13, 17). The characteristics of each category of NFC indicate the mechanism and action of the NFC upon connection/disconnection.