“…All the studies focusing on practice changes have highlighted an important decrease in the adoption of a minimally invasive approach [ 24 , 25 , 26 ]. However, these studies disagree in the implication of this paradigm shift [ 24 , 25 , 26 ].…”
Section: After the Lacc Trailmentioning
confidence: 99%
“…All the studies focusing on practice changes have highlighted an important decrease in the adoption of a minimally invasive approach [ 24 , 25 , 26 ]. However, these studies disagree in the implication of this paradigm shift [ 24 , 25 , 26 ]. Some investigations suggested that the increased adoption of open radical hysterectomy correlates with an increased risk of postoperative events [ 24 , 25 ].…”
Section: After the Lacc Trailmentioning
confidence: 99%
“…Similarly, the number of severe (grade 3 or worse) complications did not differ between the two periods (38 (6.5%) vs. 37 (5.1%); p = 0.297). More interestingly, overall and severe 90-day complications were consistent between periods, even in stages IA ( p = 0.471), IB1 ( p = 0.929), and IB2 ( p = 0.074), separately [ 26 ]. These data supported the findings observed in the LACC trial [ 13 , 14 , 15 ].…”
Radical hysterectomy and plus pelvic node dissection are the primary methods of treatment for patients with early stage cervical cancer. During the last decade, growing evidence has supported the adoption of a minimally invasive approach. Retrospective data suggested that minimally invasive surgery improves perioperative outcomes, without neglecting long-term oncologic outcomes. In 2018, the guidelines from the European Society of Gynaecological Oncology stated that a “minimally invasive approach is favored” in comparison with open surgery. However, the phase III, randomized Laparoscopic Approach to Cervical Cancer (LACC) trial questioned the safety of the minimally invasive approach. The LACC trial highlighted that the execution of minimally invasive radical hysterectomy correlates with an increased risk of recurrence and death. After its publication, other retrospective studies investigated this issue, with differing results. Recent evidence suggested that robotic-assisted surgery is not associated with an increased risk of worse oncologic outcomes. The phase III randomized Robotic-assisted Approach to Cervical Cancer (RACC) and the Robotic Versus Open Hysterectomy Surgery in Cervix Cancer (ROCC) trials will clarify the pros and cons of performing a robotic-assisted radical hysterectomy (with tumor containment before colpotomy) in early stage cervical cancer.
“…All the studies focusing on practice changes have highlighted an important decrease in the adoption of a minimally invasive approach [ 24 , 25 , 26 ]. However, these studies disagree in the implication of this paradigm shift [ 24 , 25 , 26 ].…”
Section: After the Lacc Trailmentioning
confidence: 99%
“…All the studies focusing on practice changes have highlighted an important decrease in the adoption of a minimally invasive approach [ 24 , 25 , 26 ]. However, these studies disagree in the implication of this paradigm shift [ 24 , 25 , 26 ]. Some investigations suggested that the increased adoption of open radical hysterectomy correlates with an increased risk of postoperative events [ 24 , 25 ].…”
Section: After the Lacc Trailmentioning
confidence: 99%
“…Similarly, the number of severe (grade 3 or worse) complications did not differ between the two periods (38 (6.5%) vs. 37 (5.1%); p = 0.297). More interestingly, overall and severe 90-day complications were consistent between periods, even in stages IA ( p = 0.471), IB1 ( p = 0.929), and IB2 ( p = 0.074), separately [ 26 ]. These data supported the findings observed in the LACC trial [ 13 , 14 , 15 ].…”
Radical hysterectomy and plus pelvic node dissection are the primary methods of treatment for patients with early stage cervical cancer. During the last decade, growing evidence has supported the adoption of a minimally invasive approach. Retrospective data suggested that minimally invasive surgery improves perioperative outcomes, without neglecting long-term oncologic outcomes. In 2018, the guidelines from the European Society of Gynaecological Oncology stated that a “minimally invasive approach is favored” in comparison with open surgery. However, the phase III, randomized Laparoscopic Approach to Cervical Cancer (LACC) trial questioned the safety of the minimally invasive approach. The LACC trial highlighted that the execution of minimally invasive radical hysterectomy correlates with an increased risk of recurrence and death. After its publication, other retrospective studies investigated this issue, with differing results. Recent evidence suggested that robotic-assisted surgery is not associated with an increased risk of worse oncologic outcomes. The phase III randomized Robotic-assisted Approach to Cervical Cancer (RACC) and the Robotic Versus Open Hysterectomy Surgery in Cervix Cancer (ROCC) trials will clarify the pros and cons of performing a robotic-assisted radical hysterectomy (with tumor containment before colpotomy) in early stage cervical cancer.
“…Endometrial cancer occurs in postmenopausal women with an average age at diagnosis of 60 years, and the risk factors associated with this tumor are widely known [ 15 ]. Although there is no standardized screening test for endometrial cancer, prevention is possible following healthy behaviors (prevention of obesity, weight gain, metabolic syndrome, and diabetes).…”
According to 2020 comprehensive global cancer statistics published by the International Agency for Research on Cancer, gynecologic malignancies accounted overall for 16 [...]
“…After the results of the Laparoscopic Approach to Cervical Cancer (LACC) trial, different studies are currently underway to confirm the safety of MIS in these patients in terms of oncological outcomes. By comparing MIS with open radical hysterectomy in ECC, the LACC trial unexpectedly reported inferior oncological outcomes, showing a 6.6 times greater likelihood of death associated with MIS, and lower disease-free survival (DFS) and overall survival (OS) in the MIS group [ 16 , 17 , 18 , 19 , 20 ]. The recent Multicenter study of Minimally invasive surgery versus Open Radical hysterectomy (MEMORY) study denied these findings in the management of ECC, showing that MIS compared to open radical hysterectomy for cervical cancer did not appear to compromise oncologic outcomes, with similar DFS and OS [ 21 ], and these elements was further confirmed by a more recent data analysis [ 22 ].…”
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