Practice guidelines for management of cervical cancer in Korea: a Korean Society of Gynecologic Oncology Consensus Statement

Abstract

Clinical practice guidelines for gynecologic cancers have been developed by academic society from several countries. Each guideline reflected their own insurance system and unique medical environment, based on the published evidence. The Korean Society of Gynecologic Oncology (KSGO) published the first edition of practice guidelines for gynecologic cancer treatment in late 2006; the second edition was released in July 2010 as an evidence-based recommendation. The Guidelines Revision Committee was established in 2015 and decided to develop the third edition of the guidelines in an advanced format based on evidence-based medicine, embracing up-to-date clinical trials and qualified Korean data. These guidelines cover strategies for diagnosis and treatment of primary and recurrent cervical cancer. The committee members and many gynecologic oncologists derived key questions through discussions, and a number of relevant scientific literature were reviewed in advance. Recommendations for each specific question were developed by the consensus conference, and they are summarized here, along with the details. The objective of these practice guidelines is to establish standard policies on issues in clinical practice related to the management in cervical cancer based on the results in published papers to date and the consensus of experts as a KSGO Consensus Statement.

Can simple trachelectomy or conization show comparable survival rate compared with radical trachelectomy in IA1 cervical cancer patients with lymphovascular space invasion who wish to save fertility? A systematic review and guideline recommendation

“…In the practice guidelines for cervical cancer recently revised by KSGO [ 21 ], the following question was selected as nine key questions arising in clinical situations: “Does simple trachelectomy or conization have similar survival outcome with radical trachelectomy in cervical cancer stage IA1 patients with LVSI who want to preserve fertility?” The following recommendation was suggested by the KSGO Executive Committee: “Simple trachelectomy or conization could be performed for cervical cancer IA1 patients with LVSI who want to preserve fertility, based on the similar survival outcomes from radical trachelectomy (Recommendation grade 2 = weak; Evidence level D = very low).” The “evidence profile” according to the GRADE system is shown in S4 Table .…”

“…Third, the follow-up duration was not long enough to ensure the long-term oncological outcomes with the weighted mean periods of included studies of 43 months. For these reasons, the strength of recommendation was determined as weak and the level of evidence as very low in the practice guidelines for cervical cancer by KSGO [ 21 ].…”

A Computational Approach with Biological Evaluation: Combinatorial Treatment of Curcumin and Exemestane Synergistically Regulates DDX3 Expression in Cancer Cell Lines

“…Additionally, a positive correlation was determined between overexpression of hypoxia-inducible factor 1-alpha (HIF-1α) and DDX3 expression in breast cancer [ 26 ]. Cervical cancer is one of the major cancer deaths observed in women and is ranked fourth among female cancers [ 27 ]. Therefore, in the current investigation, we aimed at finding a natural compound as an inhibitor for DDX3 in three cell lines.…”

Simple vaginal trachelectomy for early stage cervical cancer: A tertiary cancer center experience

“…However, radical trachelectomy, performed either by vaginal and abdominal route, represents as an effective treatment option with a survival rate of 95-98% in patients who desire fertility [2,3]. Many guidelines propose radical trachelectomy with lymphadenectomy for early cervical cancer patients who wish to preserve fertility [4][5][6]. However, radical trachelectomy has some morbidities.…”