Practice Gaps in Pruritus

Silverberg, Jonathan I.

doi:10.1016/j.det.2016.02.008

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…The impact of pruritus on a patient's QoL is not always appreciated by healthcare professionals; this educational gap should be addressed as a priority (120,121). Patients should also be educated in correct application of topical therapy to increase adherence.…”

Section: Unmet Needs In the Management Of Itchmentioning

confidence: 99%

Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions

Yosipovitch¹,

Miséry²,

Proksch³

et al. 2019

Acta Derm Venereol

104

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Itch is a common symptom of many skin barrier-related dermatoses and can severely impact quality of life. However, there are a limited number of effective anti-itch topical therapies currently available and several unmet needs not addressed by current itch management strategies. As our knowledge of the mechanisms underlying itch has improved, several novel therapies have recently emerged that can be incorporated into existing regimens to enhance itch therapy and management. Here, we summarise research and current opinion on available topical therapies and give recommendations for the optimal management of itch. Barrier damage, dry skin and itch are intricately linked and form the basis of many common skin diseases. Damage from environmental insults, or genetic or inflammatory causes, can impair the skin barrier, resulting in an increase in transepidermal water loss and activation of itch-associated nerve fibres. The itch-scratch cycle can perpetuate skin barrier damage and itch. Topical therapeutic strategies are utilised to overcome dry skin and itch, primarily in the form of emollients. Recent advances in our understanding of the mechanisms underlying itch have enabled the development of new topical therapies, which may be incorporated into existing treatment regimes. Ultimately, treatment of dry skin and itch must be highly tailored to the individual according to their needs.

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Section: Unmet Needs In the Management Of Itchmentioning

confidence: 99%

Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions

Yosipovitch¹,

Miséry²,

Proksch³

et al. 2019

Acta Derm Venereol

104

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“…These approaches did not include patient involvement or feedback, instead assuming that all important aspects of measuring itch were already known and/or published. However, there remain many knowledge and practice gaps in the assessment and management of itch [14]. In the present study, we used a grounded theory (GT) approach to develop a conceptual model of itch.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Conceptual Model of the Experience of Chronic Itch in Adults

et al. 2018

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“…However, the type of lesions (papules or nodules), scratching activity (monitored by excoriations or crusts on top of the pruriginous lesions pointing to scratching), distribution and number are indicative of the severity and the progress of the disease . Furthermore, although it is assumed that the healing of excoriations correlates with reduced scratching and disease improvement, so far it is not possible to assess objectively the scratching behaviour of the patient, unless devices such as actigraphy are used, which frequently do not allow inter‐individual comparisons …”

Section: Introductionmentioning

confidence: 99%

“…2,8 Furthermore, although it is assumed that the healing of excoriations correlates with reduced scratching and disease improvement, so far it is not possible to assess objectively the scratching behaviour of the patient, unless devices such as actigraphy are used, which frequently do not allow inter-individual comparisons. 9 The absence of an instrument suitable to evaluate the CPG characteristics and its course leads to limited objectivity and comparability between treatments in clinical studies and in routine care. Previous studies tried to monitor the resolution of lesions [10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%