Practice Based Evidence of the Beneficial Impact of PET in Patients with Brain Tumors

Macapinlac, Homer A.; Czernin, Johannes; Larson, Steven M.

doi:10.1007/s11307-010-0446-2

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…This dual-stain approach emphasizes the differences in the rinsing kinetics of the two stains, and thus reports specific target binding. This is consistent with recent reports demonstrating that dual-tracer imaging in vivo has the capacity to account for tracer kinetics to provide more specific molecular information [14-15]. These promising new approaches leverage the unique multi-reporter detection capabilities enabled by optical imaging to suppress the effects of reporter transport mechanisms such as blood flow, vessel perfusion, or in the case of topical staining, diffusion.…”

supporting

confidence: 88%

Topical dual-stain difference imaging for rapid intra-operative tumor identification in fresh specimens

et al. 2013

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Assessing tumor margin status during surgery is critical to ensure complete resection of cancer tissue; however, current approaches are ineffective and often result in repeat surgery. We present a novel optical imaging approach for margin assessment using topical application of two fluorescent stains, one targeted to a tumor biomarker and the other a non-targeted reference, to freshly excised specimens. Computing a normalized difference image from fluorescence images of the targeted and untargeted stains suppresses the confounding effects of non-specific uptake. Applying this approach in excised breast tumor models produced promising tumor-to-normal tissue contrasts that were significantly higher than single-targeted-stain imaging.

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supporting

confidence: 88%

Topical dual-stain difference imaging for rapid intra-operative tumor identification in fresh specimens

et al. 2013

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“…(b) Optoacoustic and (c) ultrasound cross-sections of the left thyroid lobe of the first volunteer. The optoacoustic image, leveled and normalized from 0 to 1, shows with high sensitivity vascular features of skin, muscles [1] , [2] and within the thyroid lobe [3] . The corresponding ultrasound image in grayscale also depicts Directional Power Doppler signals superimposed in color (red/blue colormaps indicating opposite flow directions).…”

Section: Figmentioning

confidence: 99%

“…Using targeted contrast agents the modality enables high sensitivity and specificity to molecular parameters of disease. Several studies have highlighted possible applications of the technique in a clinical context, including follicular thyroid carcinoma [2] , cardio vascular disease [3] , [4] and arthritis [5] . MSOT thereby operates on optoacoustic images acquired at different optical excitation wavelengths to identify contrast agents that otherwise fail to generate sufficient signal strength to be discernible from the intrinsic background absorption (e.g.…”

Section: Introductionmentioning

confidence: 99%

In-vivo handheld optoacoustic tomography of the human thyroid

Dima

Ntziachristos

2016

Photoacoustics

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We interrogated the application and imaging features obtained by non-invasive and handheld optoacoustic imaging of the thyroid in-vivo. Optoacoustics can offer complementary contrast to ultrasound, by resolving optical absorption-based and offering speckle-free imaging. In particular we inquired whether vascular structures could be better resolved using optoacoustics. For this reason we developed a compact handheld version of real-time multispectral optoacoustic tomography (MSOT) using a detector adapted to the dimensions and overall geometry of the human neck. For delivering high-fidelity performance, a curved ultrasound array was employed. The feasibility of handheld thyroid MSOT was assessed on healthy human volunteers at single wavelength. The results were contrasted to ultrasound and Doppler ultrasound images obtained from the same volunteers. Imaging findings demonstrate the overall MSOT utility to accurately retrieve optical features consistent with the thyroid anatomy and the morphology of surrounding structures.

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“…Gas diffusion out of UCAs is dependent on the concentration(Sboros et al 2000a; Mulvana et al 2012; Kabalnov et al 1998a) and type of gas in the surrounding fluid (Mullin et al 2009; Itani and Mattrey 2011) as well as the gas permeability of the UCA shell (Sboros et al 2000a; Borden and Longo 2002; Kwan and Borden 2010; Sboros et al 2000b). Smith et al (2007) investigated the diffusion of gas from ELIP and Optison® diluted in air-saturated static bovine serum albumin in a static system and insonified by (4.5 MHz, 6.0 MHz and 6.9 MHz) diagnostic ultrasound pulses.…”

Section: Introductionmentioning

confidence: 99%

Stability of Echogenic Liposomes as a Blood Pool Ultrasound Contrast Agent in a Physiologic Flow Phantom

Radhakrishnan

Haworth

Huang

et al. 2012

Ultrasound in Medicine & Biology

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Echogenic liposomes (ELIP) are multifunctional ultrasound contrast agents (UCAs) with a lipid shell encapsulating both air and an aqueous core. ELIP are being developed for molecular imaging and image-guided therapeutic delivery. Stability of the echogenicity of ELIP in physiologic conditions is crucial to their successful translation to clinical use. In this study we determined the effects of the surrounding media’s dissolved air concentration, temperature transition and hydrodynamic pressure on the echogenicity of a chemically modified formulation of ELIP to promote stability and echogenicity. ELIP samples were diluted in porcine plasma or whole blood and pumped through a pulsatile flow system with adjustable hydrodynamic pressures and temperature. B-mode images were acquired using a clinical diagnostic scanner every 5 s for a total duration of 75 s. Echogenicity in porcine plasma was assessed as a function of total dissolved gas saturation. ELIP were added to plasma at room temperature (22 °C) or body temperature (37 °C) and pumped through a system maintained at 22 °C or 37 °C to study the effect of temperature transitions on ELIP echogenicity. Echogenicity at normotensive (120/80 mmHg) and hypertensive pressures (145/90 mmHg) was measured. ELIP were echogenic in plasma and whole blood at body temperature under normotensive to hypertensive pressures. Warming of samples from room temperature to body temperature did not alter echogenicity. However, in plasma cooled rapidly from body temperature to room temperature or in degassed plasma, ELIP lost echogenicity within 20 s at 120/80 mmHg. The stability of echogenicity of a modified ELIP formulation was determined in vitro at body temperature, physiologic gas concentration and throughout the physiologic pressure range. However, proper care should be taken to ensure that ELIP are not cooled rapidly from body temperature to room temperature as they will lose their acoustic properties. Further in vivo investigations will be needed to evaluate the optimal usage of ELIP as blood pool contrast agents.

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Practice Based Evidence of the Beneficial Impact of PET in Patients with Brain Tumors

Cited by 4 publications

References 4 publications

Topical dual-stain difference imaging for rapid intra-operative tumor identification in fresh specimens

Topical dual-stain difference imaging for rapid intra-operative tumor identification in fresh specimens

In-vivo handheld optoacoustic tomography of the human thyroid

Stability of Echogenic Liposomes as a Blood Pool Ultrasound Contrast Agent in a Physiologic Flow Phantom

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