Practicality of the cyclotron production of radiolanthanide 142Pr: a potential for therapeutic applications and biodistribution studies

Sadeghi, Mahdi; Bakht, Martin; Mokhtari, L.

doi:10.1007/s10967-011-1033-y

Cited by 25 publications

(3 citation statements)

References 24 publications

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“…where N L is the Avo ga dro num ber, H -the iso tope abun dance of the tar get nu clide, M -the mass num ber of the tar get el e ment, s(E) -the cross-sec tion at energy E, I -the pro jec tile cur rent, dE/d(rx) -the stopping power, and l -the de cay con stant of the prod uct and t -the time of ir ra di a tion [15][16][17][18][19][20]. and de signed to track many par ti cle types such as neutron, pho ton, elec tron, or cou pled (neu tron/photon/elec tron ) over broad ranges of en er gies [21].…”

Section: Cal Cu La Tion Of the O Ret I Cal Yield Us Ing Talys And Sri...mentioning

confidence: 99%

Simulation of vanadium-48 production using MCNPX code

Sadeghi¹,

Mahmodi

Kakavand

et al. 2012

NUCL TECH RAD PROT

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Vanadium-48 was produced through the irradiation of the natural titanium target via the natTi(p, xn)48V reaction. The titanium target was irradiated at 1 mA current and by a 21 MeV proton beam for 4 hours. In this paper, the activity of 48V, 43Sc, and 46Sc radionuclides and the efficacy of the 47Ti(p, g), 48Ti(p, n), and 49Ti(p, 2n) channel reactions to form 48V radionuclide were determined using MCNPX code. Furthermore, the experimental activity of 48V was compared with the estimated value for the thick target yield produced in the irradiation time according to MCNPX code. Good agreement between production yield of the 48V and the simulation yield was observed. In conclusion, MCNPX code can be used for the estimation of the production yield

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Section: Cal Cu La Tion Of the O Ret I Cal Yield Us Ing Talys And Sri...mentioning

confidence: 99%

Simulation of vanadium-48 production using MCNPX code

Sadeghi¹,

Mahmodi

Kakavand

et al. 2012

NUCL TECH RAD PROT

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“…In our previous work [17], we evaluated the practicality of the cyclotron production of 142 Pr. Different reactions for the production of 142 Pr are shown in Fig.…”

Section: Production Routesmentioning

confidence: 99%

“…Interestingly, 142 Pr due to its high b --emission and low specific gamma c-emission could not only be a therapeutic radionuclide, but also a suitable radionuclide in order for biodistribution studies [17].…”

Section: Introductionmentioning

confidence: 99%

Internal radiotherapy techniques using radiolanthanide praseodymium-142: a review of production routes, brachytherapy, unsealed source therapy

Bakht

Sadeghi²

2011

Ann Nucl Med

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Radionuclides of rare earth elements are gaining importance as emerging therapeutic agents in nuclear medicine. β(-)-particle emitter 142Pr [T (1/2) = 19.12 h, E(-)β = 2.162 MeV (96.3%), Eγ = 1575 keV (3.7%)] is one of the praseodymium-141 (100% abundant) radioisotopes. Production routes and therapy aspects of 142Pr will be reviewed in this paper. However, 142Pr produces via 141Pr(n, γ) 142Pr reaction by irradiation in a low-fluence reactor; 142Pr cyclotron produced, could be achievable. 142Pr due to its high β(-)-emission and low specific gamma γ-emission could not only be a therapeutic radionuclide, but also a suitable radionuclide in order for biodistribution studies. Internal radiotherapy using 142Pr can be classified into two sub-categories: (1) unsealed source therapy (UST), (2) brachytherapy. UST via 142Pr-HA and 142Pr-DTPA in order for radiosynovectomy have been proposed. In addition, 142Pr Glass seeds and 142Pr microspheres have been utilized for interstitial brachytherapy of prostate cancer and intraarterial brachytherapy of arteriovenous malformation, respectively.

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