Practical Understanding of Hemostasis and Approach to the Bleeding Patient in the Operating Room

Pierce, Albert; Pittet, Jean–François

doi:10.1016/j.aan.2014.08.009

Cited by 6 publications

(3 citation statements)

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“…Hemostasis, a normal physiological process, occurs spontaneously to stop bleeding at the site of injury while preserving normal blood circulation. 2,3 Health care professionals have explored various methods to aid in the hemostasis process, starting from application of pressure, followed by ligation, cauterization, usage of medical vasoconstrictors, drugs, and dressings. 4 The usage of local hemostatic agents has recently received great interest, although it is a concept that has been used in various ways by many cultures.…”

Section: Introductionmentioning

confidence: 99%

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Design of nanoconstructs that exhibit enhanced hemostatic efficiency and bioabsorbability

et al. 2022

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Section: Introductionmentioning

confidence: 99%

“…Hemostasis, a normal physiological process, occurs spontaneously to stop bleeding at the site of injury while preserving normal blood circulation. 2,3…”

Section: Introductionmentioning

confidence: 99%

Design of nanoconstructs that exhibit enhanced hemostatic efficiency and bioabsorbability

et al. 2022

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“…The body's mechanism in stopping bleeding involves three main steps, including vascular spasm, formation of platelet plugs, and blood coagulation (formation of blood clots) (Sherwood, 2015). Hemostatic failure causes bleeding and is a dangerous clinical problem (Pierce & Pittet, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effect of Broccoli (Brassica oleracea L. var. italica) Extract on Bleeding Time in Male White Mice (Mus musculus L.)

Sammulia¹,

Almahdy²,

Rezky³

2020

Borneo J Pharm

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Cessation of bleeding is influenced by many factors including the type of medication used. The use of drugs to stop bleeding can be done in various ways, one of which is the use of traditional medicine. One of the traditional plants that can be used as a stop bleeding is broccoli (Brassica oleracea L. var. italica) which has a fairly high vitamin K content, where is efficacious as hemostatic. This study aims to determine the effect of broccoli on the bleeding time of mice tail cuts. The first group was negative control (Na-CMC), the second group was positive control (tranexamic acid), while groups three, four, and five were broccoli extract dose of 20, 40, and 60 mg/kg BW, respectively. All treatments were given orally for seven days. Bleeding time was calculated from the initial blood loss until the blood stopped (tail bleeding I method) and the data were analyzed with the ANOVA one way test and the post hoc Least Significant Difference (LSD) statistical test. The results showed that there were differences in the time to stop bleeding in the treatment control group at a dose of 20 mg/kg BW (122.60 � 29.535 seconds), 40 mg/kg BW (102.40 � 9.607 seconds) and 60 mg/kg BW (90.40 � 3.845 seconds). From these results, it can be concluded that the extract of broccoli at a dose of 60 mg/kg BW gives the best results as hemostatic, while the effect is almost similar to the positive control group.

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Hypovolämisch-hämorrhagischer Schock

2018

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The term "shock" refers to a life-threatening circulatory failure caused by an imbalance between the supply and demand of cellular oxygen. Hypovolemic shock is characterized by a reduction of intravascular volume and a subsequent reduction in preload. The body compensates the loss of volume by increasing the stroke volume, heart frequency, oxygen extraction rate, and later by an increased concentration of 2,3-diphosphoglycerate with a rightward shift of the oxygen dissociation curve. Hypovolemic hemorrhagic shock impairs the macrocirculation and microcirculation and therefore affects many organ systems (e.g. kidneys, endocrine system and endothelium). For further identification of a state of shock caused by bleeding, vital functions, coagulation tests and hematopoietic procedures are implemented. Every hospital should be in possession of a specific protocol for massive transfusions. The differentiated systemic treatment of bleeding consists of maintenance of an adequate homeostasis and the administration of blood products and coagulation factors.

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Practical Understanding of Hemostasis and Approach to the Bleeding Patient in the Operating Room

Cited by 6 publications

References 46 publications

Design of nanoconstructs that exhibit enhanced hemostatic efficiency and bioabsorbability

Design of nanoconstructs that exhibit enhanced hemostatic efficiency and bioabsorbability

Effect of Broccoli (Brassica oleracea L. var. italica) Extract on Bleeding Time in Male White Mice (Mus musculus L.)

Hypovolämisch-hämorrhagischer Schock

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