Practical Synthesis of Aryl Triflates under Aqueous Conditions.

Abstract

Sulfonic acids and estersSulfonic acids and esters Q 0550 Practical Synthesis of Aryl Triflates under Aqueous Conditions. -An efficient synthesis of aryl triflates from triflic anhydride and phenols either under biphasic basic aqueous conditions or under basic aqueous conditions is presented. Advantages of the present method are the avoidance of amine bases and the simple isolation by phase separation and evaporation. -(FRANTZ*, D. E.; WEAVER, D. G.; CAREY, J. P.; KRESS, M. H.; DOLLING, U. H.;

Cationic and radical intermediates in the acid photorelease from aryl sulfonates and phosphates

“…4-tert-Butylphenyltrifluoromethanesulfonate (1e) was synthesized from p-(t-butyl)phenol in 43% yield as an oil. 16 Spectroscopic data of 1e in accordance with literature data. 17 Anal.…”

Pentafluorosulfanyl (SF5) as a Superior 19F Magnetic Resonance Reporter Group: Signal Detection and Biological Activity of Teriflunomide Derivatives

“…Synthesis of TF and Its Derivatives. Fluorinated anilines were coupled with isoxazol acid chloride by a Schotten−Baumann reaction, 29,30 and the isoxazol ring of the resulting leflunomide prodrug structure was hydrolyzed for conversion into the teriflunomide derivatives 31 (Supporting Information: Chemistry, Figure S1). Derivatives of TF (Figure 1) resulted from a substitution of the para CF 3 -group on the benzene ring with a trifluoromethoxy CF 3 O-R group, two chemically symmetrical meta CF 3 groups, and one para pentafluorosulfanyl SF 5 group.…”