Practical synthesis and biological screening of sulfonyl hydrazides

Macara, João; Caldeira, Catarina; Cunha, José Emanuel; Coelho, Jaime A. S.; Silva, Maria J. S. A.; Krämer, Konrad; Grathwol, Christoph W.; Bräse, Stefan; Marques, M. Manuel B.

doi:10.1039/d2ob02160a

Cited by 2 publications

(3 citation statements)

References 27 publications

(40 reference statements)

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“…This result is consistent with previous reports, confirming that copper catalysts are efficient coupling catalysts in aerobic processes, facilitating coupling between carbon atoms and heteroatom nucleophiles. [51][52][53] However, organic copper salts such as Cu-(OAc) 2 and Cu(acac) 2 did not produce the wanted products Scheme 1. Synthetic procedures to prepare sulfonamides.…”

Section: Resultsmentioning

confidence: 99%

“…CuI, CuBr, and CuCl 2 could support the process to produce 3 a , but reaction yields were lower than that of CuBr 2 (Table 1, entries 8–10). This result is consistent with previous reports, confirming that copper catalysts are efficient coupling catalysts in aerobic processes, facilitating coupling between carbon atoms and heteroatom nucleophiles [51–53] . However, organic copper salts such as Cu(OAc) 2 and Cu(acac) 2 did not produce the wanted products (Table 1, entries 11–12), possibly due to the bulkiness of the molecules interfering with the catalytic process.…”

Section: Resultsmentioning

confidence: 99%

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Visible‐Light‐Driven Sulfonamidation of Arylazo Sulfonesthrough One‐Pot Multicomponent Reaction

Luu

Jeong

2023

Asian J Org Chem

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Sulfonamide is one of the most important structures in organic chemistry due to its frequent appearance in natural products as well as pharmaceuticals. This study reports a visible‐light‐promoted strategy for synthesis of sulfonamides from arylazo sulfones. One‐pot tri‐component reactions were conducted using arylazo sulfones, DABSO, and amines in the presence of CuBr2 as a coupling catalyst under irradiation with blue LEDs to prepare various sulfonamides in good yields under mild conditions. This method could be used effectively to produce a variety of useful sulfonamides.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Visible‐Light‐Driven Sulfonamidation of Arylazo Sulfonesthrough One‐Pot Multicomponent Reaction

Luu

Jeong

2023

Asian J Org Chem

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“…The provision of samples to the Molecule Archive has been the origin of many publications that were done in collaboration with compound providers and re-usersapproving that the provision of data can result directly in more visibility and impact for the scientists sharing their research results. 32,33,34,35,36,37,38 https://doi.org/10.26434/chemrxiv-2023-2dd4c ORCID: https://orcid.org/0000-0001-9513-2468 Content not peer-reviewed by ChemRxiv. License: CC BY 4.0 generation of, e.g., molecular descriptors facilitate the work of the scientists as the most suitable descriptors for a search for chemical compounds are generated by the software without additional efforts.…”

Section: Discussionmentioning

confidence: 99%

Supporting Sustainability of Chemistry by Linking Research Data with Physically Preserved Research Materials

Lin,

Huang,

Graessle

et al. 2023

Preprint

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Results of scientific work in chemistry can usually be obtained in the form of materials and data. A big step towards transparency and reproducibility of the scientific work can be gained if scientists publish their data in a FAIR (Findable, Accessible, Interoperable, Reusable) manner in research data repositories. Nevertheless, in order to make chemistry as a discipline sustainable, obtaining FAIR data is insufficient and a comprehensive concept including the preservation of materials is needed. We describe in this article how we combined two infrastructures, a repository for research data (Chemotion repository) and an archive for chemical compounds (Molecule Archive), in order to offer a comprehensive infrastructure to find and access data and materials that were generated in chemistry projects. Samples play a key role in this concept: we describe how FAIR metadata of a virtual sample representation can be used to refer to the physically available sample stored in a materials’ archive and to link FAIR research data gained with the sample. We further describe the measures to make the physically available samples not only FAIR through the sample’s metadata but also accessible and reusable in the form of their material for others.

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Practical synthesis and biological screening of sulfonyl hydrazides

Abstract: A methodology for the synthesis of sulfonyl hydrazides mediated by hypervalent iodine is described. Taking advantage of the umpolung properties of hypervalent iodine reagents, the polarity of sodium sulfinate salts...

Cited by 2 publications

References 27 publications

Visible‐Light‐Driven Sulfonamidation of Arylazo Sulfonesthrough One‐Pot Multicomponent Reaction

Visible‐Light‐Driven Sulfonamidation of Arylazo Sulfonesthrough One‐Pot Multicomponent Reaction

Supporting Sustainability of Chemistry by Linking Research Data with Physically Preserved Research Materials

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