Practical organic chemistry, including qualitative organic analysis

Strafford, N.

doi:10.1016/0003-2670(56)80113-x

Cited by 8 publications

(5 citation statements)

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“…The separation process involved using a separation funnel, where the upper layer consisting of ether was retained, while the lower layer containing the aqueous solution was discarded. (Arthur et al;1972). The specimens were stored in glass bottles that were not transparent and were subsequently refrigerated until they underwent analysis using the gas-liquid chromatography (GLC) instrument, enabling the investigation of their antioxidant properties.…”

Section: Separation Of Fatty Acids By the Saponification Methodsmentioning

confidence: 99%

Detection of Fatty Acids Separated from Melissa Officinalis Leaves Using GLC Technology and Studying their Effect on the Vitality of Staphylococcus Aureus

Mahmoud,

Mikhlif,

Hasan

2023

JLL

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The plant found in Mosul exhibited distinct characteristics in terms of its composition of Undecanoic acid and Linoleic acid. Notably, the highest concentration of fatty acids was observed in the leaves of the plant cultivated in the Aqrah district, measuring 9.908 mg/g. The findings of the present study demonstrate that fatty acids exhibit antioxidant properties against the free radical DPPH. Moreover, it was observed that the efficacy of these fatty acids in neutralizing the free radical increases proportionally with the concentration of the active compounds. At a concentration of 500 μg/ml, the fatty acids (Mosul) exhibited the highest level of inhibition, with a rate of 86.4%. This inhibition rate was found to be superior to that of fatty acids (Aqrah) at the same concentration, which showed an inhibition rate of 79.25%. Furthermore, the observed inhibition rate of fatty acids (Mosul) was statistically significant and comparable to the standard sample of ascorbic acid at the same concentration, which exhibited an inhibition rate of 85.6%. Following these results, the concentration of fatty acids (Mosul) is 400 micrograms per milliliter, exhibiting an inhibition rate of 81.2%. In comparison, fatty acids (Aqrah) achieved an inhibition rate of 72.3% at the same concentration. Other concentrations displayed varying degrees of inhibition capacity towards DPPH free radicals. The study provided confirmation of the inhibitory effects of fatty acids on the viability of Staphylococcus aureus strains isolated from infected individuals at Tikrit Teaching Hospital.

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Section: Separation Of Fatty Acids By the Saponification Methodsmentioning

confidence: 99%

Detection of Fatty Acids Separated from Melissa Officinalis Leaves Using GLC Technology and Studying their Effect on the Vitality of Staphylococcus Aureus

Mahmoud,

Mikhlif,

Hasan

2023

JLL

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“…Stirring was continued for 30 min to 1 h. The mixture was kept for overnight in fridge; the solid substance was filtered off, and washed with ice cold water, followed by cold ethanol. The product was recrystallized from ethanol or methanol (Hannaford et al, 1978). For hydroxylated chalcones the amount of sodium hydroxide was doubled and stirring was continued for 24-48 h, the reaction mixture was quenched with 1% aqueous hydrochloric acid, the solid substance was filtered off and washed with ice cold water and purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 8:2).…”

Section: Supplementary Materials 1 Experimental 11 Synthesis Of Chalc...mentioning

confidence: 99%

Evaluation of chalcones as new glycogen phosphorylase inhibitors – an in-vitro and in-silico approach

Awad,

Alfatih,

Shafiq

et al. 2024

Natural Product Research

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“…They were within ± 0.4 of the theoretical values. Compounds I, II, III, IVa-d, Va-d, VI, VIII, X, and XVII were synthesized according to previously reported procedures [21,46,47,49,[52][53][54][59][60][61][62][63].…”

Section: Chemistry and Analysismentioning

confidence: 99%

Design, Synthesis, and Biological Evaluation of New Potential Unusual Modified Anticancer Immunomodulators for Possible Non-Teratogenic Quinazoline-Based Thalidomide Analogs

Mabrouk

Abdallah

Mahdy

et al. 2023

IJMS

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Sixteen new thalidomide analogs were synthesized. The new candidates showed potent in vitro antiproliferative activities against three human cancer cell lines, namely hepatocellular carcinoma (HepG-2), prostate cancer (PC3), and breast cancer (MCF-7). It was found that compounds XII, XIIIa, XIIIb, XIIIc, XIIId, XIVa, XIVb, and XIVc showed IC50 values ranging from 2.03 to 13.39 µg/mL, exhibiting higher activities than thalidomide against all tested cancer cell lines. Compound XIIIa was the most potent candidate, with an IC50 of 2.03 ± 0.11, 2.51 ± 0.2, and 0.82 ± 0.02 µg/mL compared to 11.26 ± 0.54, 14.58 ± 0.57, and 16.87 ± 0.7 µg/mL for thalidomide against HepG-2, PC3, and MCF-7 cells, respectively. Furthermore, compound XIVc reduced the expression of NFκB P65 levels in HepG-2 cells from 278.1 pg/mL to 63.1 pg/mL compared to 110.5 pg/mL for thalidomide. Moreover, compound XIVc induced an eightfold increase in caspase-8 levels with a simultaneous decrease in TNF-α and VEGF levels in HepG-2 cells. Additionally, compound XIVc induced apoptosis and cell cycle arrest. Our results reveal that the new candidates are potential anticancer candidates, particularly XIIIa and XIVc. Consequently, they should be considered for further evaluation for the development of new anticancer drugs.

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Practical organic chemistry, including qualitative organic analysis

Cited by 8 publications

References 0 publications

Detection of Fatty Acids Separated from Melissa Officinalis Leaves Using GLC Technology and Studying their Effect on the Vitality of Staphylococcus Aureus

Detection of Fatty Acids Separated from Melissa Officinalis Leaves Using GLC Technology and Studying their Effect on the Vitality of Staphylococcus Aureus

Evaluation of chalcones as new glycogen phosphorylase inhibitors – an in-vitro and in-silico approach

Design, Synthesis, and Biological Evaluation of New Potential Unusual Modified Anticancer Immunomodulators for Possible Non-Teratogenic Quinazoline-Based Thalidomide Analogs

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