Practical Management of Disorders of the Liver, Pancreas, and Biliary Tract

Twiss, John Russell; Oppenheim, Elliot

doi:10.1080/00325481.1955.11711802

Cited by 7 publications

(2 citation statements)

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“…Duodenal intubation with a Jutti tube was carried out in 2 patients with the procedure described by Twiss and Oppenheim. 2 The bile was cultured and the bacterial sensitivity studied by the standard method. Then 100 mg. nitrofurantoin was administered 4 times daily for 2 days, and duodenal drainage repeated 12 hours after the last dose.…”

Section: Methods Of Studymentioning

confidence: 99%

Nitrofurantoin (Furadantin) in the biliary tract

Feder

Kahn

Flores

et al. 1960

Clin Pharma and Therapeutics

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Twiss and his co‐worker's reported that the oral administration of nitrofurantoin produced bactericidal levels of the drug in the bile. The organisms which infect the biliary tract are frequently the same as those which infeet the urinary tract. They therefore inferred that nitrofurantoin should be a valuable agent in treating infections of the biliary tract. We were unable to eradicate infections in the biliary tract even though the organisms isolated from culture of the bile were sensitive to the action of nitrofurantoin in vitro. Therefore we decided to repeat the studies of Twiss and his associates. Following the oral administration of adequate doses of nitrofurantoin, the levels of this drug were studied in bile specimens obtained trom the gall bladder by T‐tube drainage and duodenal tube drainage. Blood levels were also determined. Nitrofurantoin levels were far below those obtained by Twiss. In no instance was there any bactericidal activity of nitrofurantoin observed at levels present in the bile during treatment. Nitrofurantoin is therefore ineffective in treatment oi infections of the biliary tract.

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Section: Methods Of Studymentioning

confidence: 99%

Nitrofurantoin (Furadantin) in the biliary tract

Feder

Kahn

Flores

et al. 1960

Clin Pharma and Therapeutics

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show abstract

“…The many methods of treating pancreatic fistulae and cysts have been authoritatively discussed in a number of recent publications (Lahey and Lium, 1937;Aldis, 1946;Cattell and Warren, 1953;Sinclair, 1955;Clyne, 1955;Maingot, 1955;Twiss and Oppenheim, 1955;Aird, 1957. ) In Case 2 the opportunity was taken, at an emergency operation for obstruction, to deal with the fistula which would otherwise have been treated conservatively for a longer period.…”

Section: Treatmentmentioning

confidence: 99%