Practical Guidelines for Acute Pancreatitis

Pezzilli, Raffaele; Zerbi, Alessandro; Carlo, V. Di; Bassi, Claudio; Fave, G. F. Delle

doi:10.1159/000314602

Cited by 138 publications

(78 citation statements)

References 44 publications

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“…It has been identified as a predictor of severity in AP, but it increases late (during the first 24-48 hours), directly related with the degree of the necrosis [19]. Other authors consider that it is a sensitive predictor of the progression of severity from moderate to severe [14]; the results of its accuracy in predicting severity and mortality vary in different studies according to the time of measurement and the cutoff value used to measure it [7,8,9,14,19,26]. Plasma levels above 150mg/L within the first 72 hours of disease correlate with the presence of necrosis with a sensitivity and specificity that are both >80% [9].…”

Section: Discussionmentioning

confidence: 99%

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Biological markers of severity in acute pancreatitis

et al. 2014

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Section: Discussionmentioning

confidence: 99%

“…Severity assessment is essential for selection of appropriate initial treatment in the management of AP [8], and to identify the cohort of patients who require critical care support, in order to rationalize health care resources [4].…”

Section: Introductionmentioning

confidence: 99%

Biological markers of severity in acute pancreatitis

et al. 2014

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“…Thus we (so) realized that most studies 147,148 analyzed acute pancreatitis guidelines with the AGREE method, 139 considering 2008 as a time limit of bibliography. We therefore decided to analyze with the AGREE method (Appraisal of Guidelines, Research and Evaluation II) only the GL produced after 2008.…”

Section: The Management Of the Patient With Pancreatitis: Methodologymentioning

confidence: 99%

The management of the patient with acute pancreatitis: from evidence to clinical practice

Cenci

Restuccia

Gnerre³

et al. 2017

Ital J Med

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Acute pancreatitis is an inflammatory disorder of the pancreas characterized by abdominal pain and elevation of pancreatic enzymes in the blood. The pathogenesis is complex and partly unknown and the evolution is often unpredictable. Many efforts have been made to define this disease and its complications and to classify different grades of severity in order to formulate prognostic scores that could guide the physician in choosing the optimal therapeutic setting and procedures. The management of the patient with pancreatitis is not always optimal and differs among internist, gastroenterologist or surgeon. We think that a patient with clinical suspicion of acute pancreatitis is admitted to medical or surgical department depending on the availability of beds and not according to evidence-based medicine. The aim of this monograph is to identify the optimal management of patients with acute pancreatitis admitted to hospital.

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“…Performing a risk evaluation at the very beginning is essential to establishing appropriate treatment (grade A recommendation) [8]. Since no single method on its own is sufficiently sensitive and specific, risk evaluations must combine scoring scales, clinical assessment, and imaging tests (particularly contrast-enhanced TAC).…”

Section: Evaluating Riskmentioning

confidence: 99%