Practical guide to the management of acute pancreatitis

Goodchild, George; Chouhan, Manil; Johnson, Gavin

doi:10.1136/flgastro-2018-101102

Cited by 43 publications

(41 citation statements)

References 49 publications

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“…Diagnosis requires two out of three criteria: typical history, elevated serum amylase or lipase more than three times the upper limit of normal for the laboratory reference range and suggestive imaging findings. 4 Several viruses have been implicated in the aetiology of acute pancreatitis. These include cytomegalovirus, Epstein-Barr virus, hepatitis A-E viruses, herpes simplex virus, varicella zoster virus, mumps, measles and coxsackie virus, among others.…”

Section: Discussionmentioning

confidence: 99%

Acute pancreatitis in a patient with COVID-19

et al. 2021

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COVID-19 mainly causes pulmonary disease. Involvement of gastrointestinal and hepatobiliary systems, among other systems, has been reported. We report a case of acute pancreatitis in a patient with resolving COVID-19 pneumonia. History taking and investigations excluded other causes of pancreatitis. This case demonstrates the possibility of pancreatic injury in patients with COVID-19, in line with previously reported similar cases. We believe that it is imperative to screen patients presenting with acute pancreatitis for SARS-CoV-2. It is also important to take into consideration that patients with a complicated course who require an invasive procedure such as drainage might pose a risk of transmission to the operating surgeon or interventionist.

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Section: Discussionmentioning

confidence: 99%

Acute pancreatitis in a patient with COVID-19

et al. 2021

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“…Premature intrapancreatic activation of trypsin causes an increase in ROS and inflammatory mediators. This triggers cellular damage and clinical manifestations of the disease (Goodchild et al, 2019;Pérez et al, 2015). Previous studies have demonstrated that ROS formation is closely linked to AP (Kim, 2008;Thareja, Bhardwaj, Sateesh, & Saraya, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…levels (Goodchild et al, 2019). If the underlying causes are not treated effectively, acute recurrent pancreatitis (ARP), defined by recurrent episodes of AP, occurs (Steinberg & Tenner, 1994).…”

mentioning

confidence: 99%

Myrtus communisleaf extract protects against cerulein‐induced acute pancreatitis in rats

et al. 2019

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In this study, the aim was to examine the potential protective effects of Myrtus communis subsp. communis leaf ethanol extract (MC) treatment against acute pancreatitis (AP) in rats. Thirty‐two rats were grouped as the saline‐pretreated control (C), MC‐pretreated control (MC), saline‐pretreated AP (AP), and MC‐pretreated AP (MC + AP) groups. To induce AP, cerulein was administered (50 µg/kg) two times. The rats were given MC for 14 days before cerulein injection. Six hours after the final cerulein injection, the rats were sacrificed. Pancreatic damage was associated with an increase in the serum activity of lipase and amylase, the pancreatic activity of myeloperoxidase, and the pancreatic level of malondialdehyde, interleukin‐1β, and interleukin‐6. AP also led to a decrease in the pancreatic level of anti‐inflammatory interleukin‐10 and glutathione. Pretreatment with MC before the induction of AP significantly reduced the pancreatic damage observed during the histological examination as well as reversed the biochemical changes evoked by AP. Practical applications Acute pancreatitis is characterized by high mortality (average about 5%; severe cases may reach about 30%). The current treatment for acute pancreatitis is mainly symptomatic. The introduction of herbal drugs may lead to the development of a new strategy in the treatment of this disease. This study revealed that MC reduced pancreatic injury by decreasing pro‐inflammatory cytokines, increasing antioxidant capacity and anti‐inflammatory cytokine, IL‐10. To the authors’ knowledge, this research is the first report showing that MC inhibits the development of AP. This observation suggests that MC may be useful in the prevention and the treatment of AP in clinical settings.

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“…Las características clínicas compatibles con un episodio de pancreatitis aguda son: la aparición de un dolor abdominal continúo de localización epigástrica o periumbilical; el cual puede irradiarse hacia la espalda, exacerbarse con el movimiento, y aliviarse al reclinarse hacia adelante. El dolor abdominal usualmente se encuentra asociado a sensación de distensión abdominal, anorexia, náuseas y vómitos 46 . Los pacientes se presentarán en el cuarto de urgencias en las primeras 12 -24 horas desde el inicio del dolor abdominal 1 , y el dolor abdominal estará presente en el 90% de los casos 30 .Los pacientes con un episodio de pancreatitis aguda severa presentarán defensa y rebote a la palpación abdominal, en contraste con un episodio de pancreatitis aguda leve, en donde se presentarán con ligero dolor abdominal.…”

Section: Cuadro Clínicounclassified

Pancreatitis Aguda: Articulo de Revisión

Pérez¹,

Valdes²

2020

Rev Med Cient

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La pancreatitis aguda es una de las principales causas gastrointestinales por la cual se acude al cuarto de urgencias, y es una causa importante de morbimortalidad a nivel mundial. Se caracteriza por la activación desmedida de la tripsina en las células acinares del páncreas, provocando la autodigestión enzimática del tejido pancreático. La primera descripción de esta entidad fue realizada en el año 1652 por el médico danés Nicholaes Tulp. Sus principales etiologías son la litiasis biliar y el consumo excesivo de alcohol. Para establecer el diagnóstico de pancreatitis aguda se requieren al menos 2 de sus 3 criterios diagnósticos: dolor abdominal típico de pancreatitis, niveles de amilasa y/o lipasa séricos con elevación superior a 3 veces el límite de lo normal, hallazgos típicos de pancreatitis aguda por imagenología del abdomen. La hidratación, nutrición temprana y el manejo del dolor son los pilares en el manejo de una pancreatitis aguda

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Practical guide to the management of acute pancreatitis

Cited by 43 publications

References 49 publications

Acute pancreatitis in a patient with COVID-19

Acute pancreatitis in a patient with COVID-19

Myrtus communisleaf extract protects against cerulein‐induced acute pancreatitis in rats

Pancreatitis Aguda: Articulo de Revisión

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