Practical guide on on-line hemodiafiltration for acute liver failure

和明, 井上; 成人, 織田; 隆三, 安部; 康裕, 滝川; 伸朗, 中山; 直也, 加藤; 慶一, 藤原; 伸, 安井; 崇二, 寺井; 章雄, 井戸; 功, 坂井田; 拓哉, 玄田; 雅仁, 清水; 智, 持田; 一, 滝川

doi:10.2957/kanzo.61.47

Cited by 1 publication

(4 citation statements)

References 30 publications

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“…[361][362][363] In HEV-ALF patients with encephalopathy, artificial liver support, such as high-flow continuous hemodiafiltration, on-line hemodiafiltration, and/or plasma exchange, should be performed, because it is important for a better prognosis to improve disturbance of consciousness. [363][364][365][366][367][368][369][370] Recent reports have demonstrated that the rate of consciousness regain is ~90% by on-line hemodiafiltration with or without slow plasma exchange in Japanese leading liver units. [366][367][368][369][370] Artificial liver support is important for recovery from critical conditions and for bridging liver transplantation for patients with HEV-ALF.…”

Section: Artificial Liver Support and Liver Transplantationmentioning

confidence: 99%

“…[363][364][365][366][367][368][369][370] Recent reports have demonstrated that the rate of consciousness regain is ~90% by on-line hemodiafiltration with or without slow plasma exchange in Japanese leading liver units. [366][367][368][369][370] Artificial liver support is important for recovery from critical conditions and for bridging liver transplantation for patients with HEV-ALF. [366][367][368][369][370] Due to the shortage of deceased donors and the aging of patients with HEV-ALF in Japan, it may be difficult to perform liver transplantation for patients with HEV-ALF.…”

Section: Artificial Liver Support and Liver Transplantationmentioning

confidence: 99%

“…[366][367][368][369][370] Artificial liver support is important for recovery from critical conditions and for bridging liver transplantation for patients with HEV-ALF. [366][367][368][369][370] Due to the shortage of deceased donors and the aging of patients with HEV-ALF in Japan, it may be difficult to perform liver transplantation for patients with HEV-ALF. Shimata et al reported successful living-donor liver transplantation for a 63-year-old Japanese man with fulminant hepatitis associated with HEV infection.…”

Section: Artificial Liver Support and Liver Transplantationmentioning

confidence: 99%

“…� High-flow continuous hemodiafiltration or on-line hemodiafiltration with or without plasma exchange can be performed until hepatic encephalopathy in HEV-ALF patients improves. [366][367][368][369][370] (B-2)…”

Section: Consensus Statements and Recommendationsmentioning

confidence: 99%

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Recent advances in hepatitis E virus research and the Japanese clinical practice guidelines for hepatitis E virus infection

Kanda,

Li,

Takahashi

et al. 2024

Hepatology Research

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Acute hepatitis E was considered rare until reports emerged affirming the existence of hepatitis E virus (HEV) genotypes 3 and 4 infections in Japan in the early 2000s. Extensive studies by Japanese researchers have highlighted the pivotal role of pigs and wild animals, such as wild boars and deer, as reservoirs for HEV, linking them to zoonotic infections in Japan. Currently, when hepatitis occurs subsequent to the consumption of undercooked or grilled pork, wild boar meat, or offal (including pig liver and intestines), HEV infection should be considered. Following the approval of anti‐HEV immunoglobulin A antibody as a diagnostic tool for hepatitis E by Japan's Health Insurance System in 2011, the annual number of diagnosed cases of HEV infection has surged. Notably, the occurrence of post‐transfusion hepatitis E promoted nationwide screening of blood products for HEV using nucleic acid amplification tests since 2020. Furthermore, chronic hepatitis E has been observed in immunosuppressed individuals. Considering the significance of hepatitis E, heightened preventive measures are essential. The Japan Agency for Medical Research and Development Hepatitis A and E viruses (HAV and HEV) Study Group, which includes special virologists and hepatologists, held a virtual meeting on February 17, 2024. Discussions encompassed pathogenesis, transmission routes, diagnosis, complications, severity factors, and ongoing and prospective vaccination or treatments for hepatitis E. Rigorous assessment of referenced studies culminated in the formulation of recommendations, which are detailed within this review. This comprehensive review presents recent advancements in HEV research and Japanese clinical practice guidelines for HEV infection.

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