Practical guide for the management of hypertensive disorders during pregnancy

Antza, Christina; Stabouli, Stella; Kotsis, V.

doi:10.1097/hjh.0000000000003194

Cited by 4 publications

(2 citation statements)

References 78 publications

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“…Hypertension during pregnancy is a major contributor to maternal and perinatal mortality 10 , 11 . We found that women with preeclampsia/eclampsia had a higher risk of cesarean section.…”

Section: Discussionmentioning

confidence: 99%

Maternal-fetal outcomes of women with hypertensive disorders of pregnancy

Xavier,

Simões,

Oliveira

et al. 2023

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: The objective of this study was to determine adverse maternal and perinatal outcomes in pregnant women with hypertensive disorders of pregnancy. METHODS: An analytical cross-sectional study was conducted on women admitted with hypertensive disorders of pregnancies to a university maternity hospital from August 2020 to August 2022. Data were collected using a pretested structured questionnaire. Variables associated with adverse maternal and perinatal outcomes were compared using multivariable binomial regression. RESULTS: Of 501 women with pregnancies, 2, 35, 14, and 49% had eclampsia, preeclampsia, chronic hypertension, and gestational hypertension, respectively. Women with preeclampsia/eclampsia had significantly higher risks of cesarean section (79.4 vs. 65%; adjusted RR, 2,139; 95%CI, 1,386–3,302; p=0.001) and preterm delivery at <34 weeks’ gestation (20.5 vs. 6%; adjusted RR, 2.5; 95%CI, 1.19–5.25; p=0.01) than those of women with chronic/gestational hypertension. Risks of prolonged maternal hospitalization (43.9 vs. 27.1%), neonatal intensive care unit admission (30.7 vs. 19.8%), and perinatal mortality (23.5 vs. 11.2%) were higher among women with preeclampsia/eclampsia. CONCLUSIONS: Women with preeclampsia/eclampsia had a higher risk of adverse maternal and neonatal outcomes than those with chronic or gestational hypertension. This major maternity care center requires strategies for preventing and managing preeclampsia/eclampsia to improve pregnancy outcomes.

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“…Hypertension during pregnancy is a major contributor to maternal and perinatal mortality 10 , 11 . We found that women with preeclampsia/eclampsia had a higher risk of cesarean section.…”

Section: Discussionmentioning

confidence: 99%

Maternal-fetal outcomes of women with hypertensive disorders of pregnancy

Xavier,

Simões,

Oliveira

et al. 2023

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

show abstract

“…We aimed to evaluate the ability to define the risk of developing preeclampsia by a screening test carried out in the first trimester (between 11 + 0 and 13 + 6 weeks of gestational age). The calculation of the risk is the result of the association of risk factors such as nulliparity, Afro-Caribbean ethnicity, BMI ≥ 30, chronic maternal hypertension, obstetric history, positive family history of PE, positive obstetric history of intrauterine fetal death (IUFD), or intrauterine growth restriction (IUGR), serum levels of PAPP-A (Pregnancy-Associated Plasma Protein A) and PlGF (Placental Growth Factor), ultrasound measurement of the pulsatility index of uterine arteries (PI), and mean arterial pressure (MAP) [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Results of a Five-Year Experience in First Trimester Preeclampsia Screening

Capriglione

Gulino²,

Latella³

et al. 2022

JCM

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Background and Objectives: The study aimed to evaluate the ability defining the risk of developing preeclampsia by a screening test carried out in the first trimester (between 11 + 0 and 13 + 6 weeks of gestational age), in order to identify high-risk women requiring more intensive health surveillance. The secondary objective was to evaluate the ability of this test to predict the risk of adverse obstetric outcomes such as fetal growth restriction, intrauterine fetal death, gestational hypertension, HELLP syndrome, placental abruption, and preterm birth. Materials and Methods: This was a single-center study, conducted at the Operative Unit of Obstetrics of the State Hospital of the Republic of San Marino. Medical history was collected at the time of enrolment in writing. Subsequently, obstetric outcomes were collected for each enrolled woman, through the analysis of medical records. Results: From October 2014 to May 2019, 589 pregnant women were recruited, of whom, 474 (80.5%) were included in the “low-risk” group, and 115 (19.5%) in the “high-risk” group. At the time of analysis of this population, the obstetric outcomes were available for 498 women (84.5%), while 91 cases (15.5%) were current pregnancies. The PI of the uterine arteries was not significantly different between the two study groups. Otherwise, a significant difference was highlighted for MAP, which is higher in the case of pregnancies at high risk based on the risk factors only, and for PAPP-A, higher in the case of low-risk pregnancies. Regarding the percentage of fetal DNA, according to the most recent literature data, in our series, we report a statistically significant difference of the average between the low and high-risk groups. Conclusions: In our study, we demonstrate that the multiparametric screening test for early PE performed well in identifying women at high risk of early PE, which certainly has the most severe maternal–fetal outcomes. The data reported that ASA intake at low doses is significantly higher in the population with high-risk tests for both early PE and late PE suggest once again that anamnestic evaluation plays an essential role in women’s screening.

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Maternal exposure to bioclimatic stress and hypertensive disorders of pregnancy in Western Australia: identifying potential critical windows of susceptibility

Gebremedhin,

Nyadanu,

Hanigan

et al. 2024

Environ Sci Pollut Res

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The anthropogenic climate change may impact pregnancy outcomes. Rather than ambient temperature, we aimed to use a composite bioclimatic metric (Universal Thermal Climate Index, UTCI) to identify critical susceptible windows for the associations between bioclimatic exposure and hypertensive disorders of pregnancy (HDPs) risk. Daily UTCI exposure from 12 weeks of preconception through pregnancy was linked to 415,091 singleton pregnancies between 1st January 2000 and 31st December 2015 in Western Australia. Adjusted weekly-specific and cumulative odds ratios (ORs) and 95% confidence intervals (CIs) of gestational hypertension and preeclampsia were estimated with distributed lag non-linear and standard non-linear logistic regressions. Exposures from early pregnancy to week 30 were associated with greater odds of HDPs with critical susceptible windows, particularly elevated at the 1st (10.2 °C) and 99th (26.0 °C) exposure centiles as compared to the median (14.2 °C). The most elevated ORs were 1.07 (95% CI 1.06, 1.08) in weeks 8–18 for gestational hypertension and 1.10 (95% CI 1.08, 1.11) in weeks 11–16 for preeclampsia for the 99th exposure centile. Cumulative exposures associated with HDPs with relatively higher but less precise ORs. The effects of high exposure to HDPs indicated sociodemographic inequalities. The identified critical periods and subpopulations could benefit from climate-related interventions.

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Practical guide for the management of hypertensive disorders during pregnancy

Cited by 4 publications

References 78 publications

Maternal-fetal outcomes of women with hypertensive disorders of pregnancy

Maternal-fetal outcomes of women with hypertensive disorders of pregnancy

Results of a Five-Year Experience in First Trimester Preeclampsia Screening

Maternal exposure to bioclimatic stress and hypertensive disorders of pregnancy in Western Australia: identifying potential critical windows of susceptibility

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