Practical Guide for Radiological Diagnosis of Primary and Secondary Sclerosing Cholangitis

Pria, Hanna Dalla; Torres, Ulysses S.; Faria, Silvana C.; Velloni, Fernanda; Caiado, Angela H.M.; Tiferes, Dario Ariel; D'Ippólito, Giuseppe

doi:10.1053/j.sult.2022.06.007

Cited by 4 publications

(1 citation statement)

References 57 publications

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“…Currently, there are no effective drugs identified to halt the progression of the disease. Diagnosing PSC can be challenging, as noted by Pria et al [2]. The gold standard for initial non-invasive diagnostics is magnetic resonance cholangiopancreatography (MRCP) [3,4].…”

Section: Introductionmentioning

confidence: 99%

Serum Galectin-3 as a Non-Invasive Marker for Primary Sclerosing Cholangitis

Bajraktari,

Elger,

Huss

et al. 2024

IJMS

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Primary sclerosing cholangitis (PSC) is a serious liver disease associated with inflammatory bowel disease (IBD). Galectin-3, an inflammatory and fibrotic molecule, has elevated circulating levels in patients with chronic liver disease and inflammatory bowel disease (IBD). This study aims to clarify whether galectin-3 can differentiate between patients with IBD, PSC, and PSC-IBD. Our study measured serum galectin-3 levels in 38 healthy controls, 55 patients with IBD, and 22 patients with PSC (11 patients had underlying IBD and 11 patients did not), alongside the urinary galectin-3 of these patients and 18 controls. Serum and urinary galectin-3 levels in IBD patients were comparable to those in controls. Among IBD patients, those with high fecal calprotectin, indicating severe disease, exhibited lower serum and elevated urinary galectin-3 levels compared to those with low calprotectin levels. Serum galectin-3 levels were inversely correlated with C-reactive protein levels. PSC patients displayed higher serum and urinary galectin-3 levels than IBD patients, with the highest serum levels observed in PSC patients with coexisting IBD. There was no correlation between serum and urinary galectin-3 levels and laboratory indicators of liver injury in both IBD and PSC patients. In conclusion, this study demonstrates that serum and urinary galectin-3 levels can distinguish IBD from PSC patients, and also reveals higher serum galectin-3 levels in PSC-IBD patients compared to those with isolated PSC.

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Section: Introductionmentioning

confidence: 99%