Practical guide for interpreting and reporting cardiac PET measurements of myocardial blood flow: an Information Statement from the American Society of Nuclear Cardiology, and the Society of Nuclear Medicine and Molecular Imaging

Bateman, Timothy M.; Heller, Gary V.; Calnon, Dennis A.; Case, James A.; deKemp, Rob; DePuey, E. Gordon; Carli, Marcelo Di; Güler, Emel; Murthy, Venkatesh L.; Rosenblatt, Jeffrey; Sher, Ronald; Slomka, Piotr J.; Ruddy, Terrence D.

doi:10.1007/s12350-021-02552-7

Cited by 32 publications

(12 citation statements)

References 21 publications

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“…Multisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory response that commonly develops within 2-6 weeks following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, requiring hospitalization in the acute phase (Ballin & Nordström, 2021). While multiple cohorts have shown that MIS-C patients may present with heterogeneous signs that include hemodynamic instability, tachycardia, left ventricular dysfunction, and respiratory distress, possibly primary or caused by cardiac dysfunction (Bateman et al, 2021;Bongers et al, 2011) the pathophysiology of MIS-C and its natural course are yet to be fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

In‐depth cardiovascular and pulmonary assessments in children with multisystem inflammatory syndrome after SARS‐CoV‐2 infection: A case series study

Astley

Pereira

Lima

et al. 2022

Physiological Reports

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We assessed PET‐CT myocardial blood flow (MBF) using N‐13 ammonia, brachial flow‐mediated dilation, and cardiopulmonary exercise test in five post‐discarged MIS‐C survivors. None of the patients (median age: 9, range: 7‐18 years; 3 females; 2 males) had preexisting pediatric chronic conditions. At the follow‐up visit, two patients exhibited severe perfusion defect developed in the left ventricular cavity, suggesting extensive myocardial ischemia (MBF <2.0) and one patient showed persistent mild pericardial effusion. Others two patients demonstrated endothelial dysfunction. Nevertheless, all patients had lower predicted values in the VO2peak, VO2VAT, OUES, and O2 Pulse (range: 35.2%–64.5%; 15.6%–38.2%; 1.0–1.3 L/min; 4–7 ml/beat), respectively. Our d suggested that previously health MIS‐C patients had impaired MBF, endothelial dysfunction and lower cardiopulmonary capacity at follow‐up analysis. Multidisciplinary further investigations should be conducted to reinforce these findings.

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Section: Introductionmentioning

confidence: 99%

In‐depth cardiovascular and pulmonary assessments in children with multisystem inflammatory syndrome after SARS‐CoV‐2 infection: A case series study

Astley

Pereira

Lima

et al. 2022

Physiological Reports

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“…In addition, PET MPI with myocardial blood flow reserve (MBFR) is considered reasonable (LOR 2A) to diagnose microvascular dysfunction and enhance risk stratification in patients with stable chest pain and non-obstructive CAD. 1 We are very pleased that the guideline writers recognized both the superior prognostic power of PET MPI and PET myocardial blood flow [2][3][4] as well as the continued strong role of SPECT in informing day-to-day patient management. Many of the key points that we applaud were not present in earlier iterations of the document.…”

Section: The Positivementioning

confidence: 99%

ASNC’s thoughts on the AHA/ACC chest pain guidelines

Thompson

Al‐Mallah

Calnon

et al. 2022

Journal of Nuclear Cardiology

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“…For measurement of myocardial blood ow (MBF) at rest and at pharmacological stress (adenosineinduced hyperemia), 13N-Ammonia was administered intravenously (0,286 mCi/kg) over a 10-sec period, the intravenous line was ushed with additional saline over a 10-sec interval and standardized imaging protocols were performed according to the American Society of Nuclear Cardiology guidelines (2). Stress imaging was performed identically, after adenosine infusion over 6 minutes (0.142 mg/min/kg).…”

Section: N-ammonia Pet-ct Imaging Protocolmentioning

confidence: 99%

In-depth cardiovascular and pulmonary assessments in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a case series study

Astley

Pereira

Lima

et al. 2022

Preprint

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Objective To perform an in-depth assessment of cardiovascular and pulmonary outcomes in a series of 5 post discharged multisystem inflammatory syndrome (MIS-C) survivors. Methods Data were collected ≅1.9 month after hospital discharge at a tertiary hospital in São Paulo, Brazil. All patients (7-18 years; 3 females) fulfilled the MIS-C diagnosis according to CDC. The battery of tests included: 13 N-ammonia PET-CT imaging, standard echocardiography, brachial flow-mediated dilation using a Doppler ultrasound, cardiopulmonary exercise test, and blood markers. Results Upon PET-CT scans, two patients exhibited severe perfusion defect developed in the left ventricular cavity suggesting extensive myocardial ischemia, and one patient showed persistent mild pericardial effusion. Other two patients had endothelial dysfunction. All patients exhibited abnormal cardiopulmonary reserve during exercise (e.g., low VO2peak). Three patients had abnormal values for D-dimer and fibrinogen. Conclusion This study reveals novel pathological findings in MIS-C patients, which may help optimize treatment protocols in this condition.

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Practical guide for interpreting and reporting cardiac PET measurements of myocardial blood flow: an Information Statement from the American Society of Nuclear Cardiology, and the Society of Nuclear Medicine and Molecular Imaging

Cited by 32 publications

References 21 publications

In‐depth cardiovascular and pulmonary assessments in children with multisystem inflammatory syndrome after SARS‐CoV‐2 infection: A case series study

In‐depth cardiovascular and pulmonary assessments in children with multisystem inflammatory syndrome after SARS‐CoV‐2 infection: A case series study

ASNC’s thoughts on the AHA/ACC chest pain guidelines

In-depth cardiovascular and pulmonary assessments in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a case series study

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