Practical evaluation and management of cutaneous lymphoma

Fung, Maxwell A.; Murphy, Michael J.; Hoss, Diane M.; Grant‐Kels, Jane M.

doi:10.1067/mjd.2002.121355

Cited by 88 publications

(83 citation statements)

References 245 publications

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“…Localized radiation therapy or surgical excision for solitary or localized lesionsis the preferred treatment for C-ALCL [11]. Systemic therapy is indicated for patients refractory to local therapy, multifocal disease like our patient, and/or extracutaneous spread of disease.…”

Section: Open Accessmentioning

confidence: 99%

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A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in a Young Patient

Elloudi¹,

Elmahi²,

Baybay³

et al. 2016

IJCR

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Section: Open Accessmentioning

confidence: 99%

“…Combination chemotherapy is not indicated in the first intension, but In view of an aggressive clinical course, and based on the available research [11][12][13], our patient was treated with chemotherapy type CHOEP. Unfortunately, this tumor has a tendency to recur, even after long disease-free intervals.…”

Section: Open Accessmentioning

confidence: 99%

A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in a Young Patient

Elloudi¹,

Elmahi²,

Baybay³

et al. 2016

IJCR

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“…6 The presence or absence of multiple sites of involvement, antecedent history, peripheral blood involvement, tempo and pattern of progression (aggressive or chronic), and association with other local or systemic diseases (contact dermatitides or autoimmune disease such as lupus) are important considerations not only for the diagnosis but also to distinguish the lesion from pseudolymphoma (reactive lymphoid proliferations that very closely mimic lymphoma). In addition, many types of cutaneous lymphoma can have similar histomorphologic features-for example, some tumoral lesions of mycosis fungoides (MF) with large cell transformation cannot be reliably distinguished from anaplastic large cell lymphoma or lymphomatoid papulosis by hematoxylin-eosin sections or even IHC.…”

Section: The Role Of Morphology In the Initial Workupmentioning

confidence: 99%

Best Practices in Diagnostic Immunohistochemistry: Workup of Cutaneous Lymphoid Lesions in the Diagnosis of Primary Cutaneous Lymphoma

Dewar¹,

Andea²,

Guitart³

et al. 2015

Archives of Pathology & Laboratory Medicine

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Context.-Primary cutaneous lymphoma is a common extranodal non-Hodgkin lymphoma. These lesions share common features with their nodal counterparts, but also have differences in morphology, unique clinical presentations, and immunohistochemical features.Objective. - Data Sources.-The WHO and EORTC classification publications and the relevant recent literature were used to compile appropriate and practical guidelines in this review.Conclusions.-The practice of dermatopathology and hematopathology varies widely. Thus, while this review provides an overview and guideline for the workup of lymphoid lesions of the skin, the practitioner should understand the importance of clinical correlation as well as appropriate utility of available resources (such as clonality testing) in arriving at a diagnosis in cutaneous lymphoid lesions.

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“…However, the immunohistochemical examination is essential to complement the classification of cutaneous lymphomas. It initially differentiates among T, B, and NK cell lymphomas and then assists in classifying among these groups 12,13 . The search for the clonality of the TCR gene (T lymphocytes) or the heavy chains of immunoglobulins (B lymphocytes) is performed by polymerase chain reaction (PCR) or Southern blot and allows the detection of monoclonal populations, which are highly suggestive of malignant lymphoproliferative disorders.…”

Section: Diagnosis/examsmentioning

confidence: 99%

Cutaneous lymphomas: A review

Miyashiro¹,

Sanches²

2015

Cumhuriyet Med J

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SUMMARYSkin may be affected by non-Hodgkin lymphomas, and it is the second most frequently involved extranodal organ, after the gastrointestinal tract. Cutaneous lymphomas may originate from T, B, or NK lymphocytes. Diagnosis is difficult, and knowledge of these diseases is important to ensure their detection and adequate treatment and follow-up. Clinical picture is heterogeneous, and histology is essential to confirm the diagnosis. The classification is given by the correlation between clinical findings, histology and immunophenotyping. Therapeutic options include skin-directed therapies, immunomodulatory or low-dose immunosuppressive drugs. Rare cases of aggressive disease require systemic multidrug chemotherapy. The purpose of this review is to describe the ontogeny of T, B and NK lymphocytes, and to detail the most accepted classification of cutaneous lymphomas, proposed by the World Health Organisation and European Organisation for Research and Treatment of Cancer. Treatment of cutaneous lymphomas will be briefly discussed.

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Practical evaluation and management of cutaneous lymphoma

Cited by 88 publications

References 245 publications

A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in a Young Patient

A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in a Young Patient

Best Practices in Diagnostic Immunohistochemistry: Workup of Cutaneous Lymphoid Lesions in the Diagnosis of Primary Cutaneous Lymphoma

Cutaneous lymphomas: A review

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