Practical Enzymatic Production of Carbocycles

Wang, Weijin; Taber, Douglass F.; Renata, Hans

doi:10.1002/chem.202101232

Cited by 4 publications

(1 citation statement)

References 283 publications

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“…From a retrosynthetic point of view, biocatalysis complements chemistry with a broad diversity of selective functional group interconversions. However, the number of practical disconnections, especially for C–C bond formation, is still limited and needs further development. ,,− Additional biotransformations that are expected to have a future impact in API synthesis are alkylation, halogenations, C–H functionalizations, glycosylations, ,, and amide formation …”

Section: Discussionmentioning

confidence: 99%

Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods

et al. 2021

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Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic processes launched in the first half of the last century exploited whole-cell microorganisms where the specific enzyme at work was not known. In the meantime, novel molecular biology methods, such as efficient gene sequencing and synthesis, triggered breakthroughs in directed evolution for the rapid development of process-stable enzymes with broad substrate scope and good selectivities tailored for specific substrates. To date, enzymes are employed to enable shorter, more efficient, and more sustainable alternative routes toward (established) small molecule APIs, and are additionally used to perform standard reactions in API synthesis more efficiently. Herein, large-scale synthetic routes containing biocatalytic key steps toward >130 APIs of approved drugs and drug candidates are compared with the corresponding chemical protocols (if available) regarding the steps, reaction conditions, and scale. The review is structured according to the functional group formed in the reaction.

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Section: Discussionmentioning

confidence: 99%

Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods

et al. 2021

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Reaching New Biocatalytic Reactivity Using Continuous Flow Reactors

Cosgrove

Mattey

2022

Chemistry A European J

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The use of flow reactors in biocatalysis has increased significantly in recent years. Chemists have begun to design flow systems that even allow new biocatalytic reactions to take place. This concept article will focus on the design of flow systems that have allowed enzymes to go beyond their limits in batch. The case is made for moving towards fully continuous systems. With flow chemistry increasingly seen as an enabling technology for automated synthesis, and with advancements in AI‐assisted enzyme design, there is a real possibility to fully automate the development and implementation of a continuous biocatalytic processes. This will lead to significantly improved enzyme processes for synthesis.

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