Damage data on low-to-mid-rise Reinforced Concrete (RC) buildings, collected during the UK Earthquake Engineering Field Investigation Team post-earthquake reconnaissance mission on the August 24 Central Italy earthquake, are employed to derive empirical fragility relationships. Given the small dataset, the new data distributions are used for the Bayesian update of fragility functions derived for the L'Aquila earthquake (same seismic region and similar construction typologies). Other properties such as number of storeys, age of construction and shape in plan of the buildings are also analyzed. This information is employed to assess the ability of the FAST method to predict damage states in non-regular infilled RC buildings for the municipalities of Amatrice, Accumoli, Arquata del Tronto and Norcia, all severely affected by the 2016 Central Italy sequence. FAST is a spectral-based method to derive capacity curves and peak ground acceleration damage state thresholds for buildings. It is a dedicated methodology for regular RC frame buildings with masonry infills, first calibrated on damage data from the 2009 L'Aquila earthquake and applied to the 2011 Lorca (Spain), the 2012 Emilia (Italy) events for damage backanalyses. The new data from the August 2016 Central Italy earthquake provide a test-bed for FAST further employments in case of less homogenous building samples. The application of FAST presented here accounts for different shake-maps produced by both the United States Geological Survey and the Italian National Institute of Geophysics and Volcanology which are significantly different and representative of different refinements of the demand scenario. For the area of Amatrice, where the two shake-maps provide similar estimates and the buildings considered match reasonably well the typology for which FAST is calibrated, the comparison between damage level observed and as provided by