Practical Application of Levothyroxine-Based Therapy

Abstract

Levothyroxine (LT4) is a natural, endogenous hormone. Adverse events associated with this treatment are mostly symptoms of over-treatment (a state of functional thyrotoxicosis), which can be avoided by careful titration of the LT4 dosage to keep thyrotropin within an appropriate reference range that is relevant to the needs of the individual patient.