Practical and clinical applications of pancreatic magnetic resonance elastography: a systematic review

Steinkohl, Emily; Bertoli, Davide; Hansen, Tore; Olesen, Søren Schou; Drewes, Asbjørn Mohr; Frøkjær, Jens Brøndum

doi:10.1007/s00261-021-03143-3

Cited by 17 publications

(15 citation statements)

References 54 publications

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“…MRE of pancreas is at an early stage. Recent studies have used MRE to differentiate healthy from pathological pancreatic tissue[ 86 ]. The normal pancreatic stiffness in adults measured by MRE is 1.1–1.21 kPa[ 86 ].…”

Section: Mrimentioning

confidence: 99%

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Advances in the imaging of gastroenteropancreatic neuroendocrine neoplasms

Ramachandran¹,

Madhusudhan²

2022

WJG

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Gastroenteropancreatic neuroendocrine neoplasms comprise a heterogeneous group of tumors that differ in their pathogenesis, hormonal syndromes produced, biological behavior and consequently, in their requirement for and/or response to specific chemotherapeutic agents and molecular targeted therapies. Various imaging techniques are available for functional and morphological evaluation of these neoplasms and the selection of investigations performed in each patient should be customized to the clinical question. Also, with the increased availability of cross sectional imaging, these neoplasms are increasingly being detected incidentally in routine radiology practice. This article is a review of the various imaging modalities currently used in the evaluation of neuroendocrine neoplasms, along with a discussion of the role of advanced imaging techniques and a glimpse into the newer imaging horizons, mostly in the research stage.

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Section: Mrimentioning

confidence: 99%

“…Recent studies have used MRE to differentiate healthy from pathological pancreatic tissue[ 86 ]. The normal pancreatic stiffness in adults measured by MRE is 1.1–1.21 kPa[ 86 ]. Shi et al [ 87 ] used MRE for the characterization of solid pancreatic masses.…”

Section: Mrimentioning

confidence: 99%

Advances in the imaging of gastroenteropancreatic neuroendocrine neoplasms

Ramachandran¹,

Madhusudhan²

2022

WJG

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“…MRE assesses the mechanical properties of tissue and provides information about soft tissue stiffness (24). The application of MRE in the pancreas is relatively new but has shown great potential in characterizing different pancreatic diseases, including inflammation and cancer (15). MRE-derived stiffness is mainly influenced by changes in cell distribution in the extracellular matrix and might detect even subtle morphological changes in the pancreas, including periductal, intra-, and interlobular fibrosis, which dominate at the beginning of the CP disease (15).…”

Section: Discussionmentioning

confidence: 99%

“…The application of MRE in the pancreas is relatively new but has shown great potential in characterizing different pancreatic diseases, including inflammation and cancer (15). MRE-derived stiffness is mainly influenced by changes in cell distribution in the extracellular matrix and might detect even subtle morphological changes in the pancreas, including periductal, intra-, and interlobular fibrosis, which dominate at the beginning of the CP disease (15). Accordingly, as supported by our findings, MRE-derived increased stiffness could probably reflect earlier parenchymal changes, appearing before severe atrophy and the associated loss of exo- and endocrine functions develops.…”

Section: Discussionmentioning

confidence: 99%

“…Magnetic resonance elastography (MRE) assesses mechanical tissue properties and allows the evaluation of soft tissue stiffness (12). Previous studies combining histological and MRE-based assessments have shown that pancreatic stiffness increases with fibrosis and inflammation (13)(14)(15)(16). T1 mapping offers tissue information by measuring the specific T1 relaxation time, which is likely related to pancreatic fibrosis, atrophy, and edema, as in liver and pancreas studies strongly correlated with fibrosis (14,16,17).…”

Section: Introductionmentioning

confidence: 99%

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Quantification of parenchymal fibrosis in chronic pancreatitis: relation to atrophy and pancreatic function

et al. 2022

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Background Non-invasive modalities for assessing chronic pancreatitis (CP) are needed in clinical practice. Purpose To investigate the correlation between magnetic resonance elastography (MRE)-derived stiffness and T1 relaxation times (as proxies of fibrosis) and explore their relationships to gland volume and pancreatic functions in patients with CP and healthy controls (HCs). Material and Methods In 49 patients with CP and 35 HCs, pancreatic stiffness, T1 relaxation times, and gland volume were assessed. Fecal elastase and the presence of diabetes were used to evaluate pancreatic exocrine and endocrine functions. Uni- and multivariable linear regression models were used to analyze correlations between imaging parameters. Results There was a positive correlation between MRE-derived stiffness and T1 relaxation times in patients with CP (R2 = 0.42; P < 0.001) and HCs (R2 = 0.14; P = 0.028). There was no correlation between MRE-derived stiffness and gland volume in patients (R2 = 0.007; P = 0.065) or HCs (R2 = 0.010; P = 0.57). T1 relaxation time was correlated to gland volume (R2 = 0.19; P = 0.002) in patients with CP but not in the HCs ( P = 0.056). Severity of pancreatic functional impairment was reflected by increased fibrosis-related parameters in patients without functional impairment, followed by a further increase in fibrosis-related parameters and reduction in gland volume in patients with pancreatic functional impairments. Conclusion Pancreatic MRE-derived stiffness and T1 relaxation times might reflect early pathophysiological changes in CP. The dynamic correlation with pancreatic function suggests that these parameters may be useful for the non-invasive and early identification of CP.

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Abdominal Imaging for the Diagnosis of Chronic Pancreatitis

Irisawa

Yamamiya

2023

The Pancreas

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Practical and clinical applications of pancreatic magnetic resonance elastography: a systematic review

Cited by 17 publications

References 54 publications

Advances in the imaging of gastroenteropancreatic neuroendocrine neoplasms

Advances in the imaging of gastroenteropancreatic neuroendocrine neoplasms

Quantification of parenchymal fibrosis in chronic pancreatitis: relation to atrophy and pancreatic function

Abdominal Imaging for the Diagnosis of Chronic Pancreatitis

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