Practical advantages of contrast-enhanced ultrasound in abdominopelvic radiology

Ranganath, Praveen; Robbin, Michelle L.; Back, Susan J.; Grant, Edward G.; Fetzer, David T.

doi:10.1007/s00261-017-1442-7

Cited by 22 publications

(17 citation statements)

References 48 publications

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“…5 The spatial resolution of ultrasound (US) is often superior to that of CT or MRI, which is particularly useful in small masses. 6 The ability to image in real time can provide more complete information about a lesion's enhancement pattern during the entire postcontrast period and allows for the generation of time-intensity curves. CEUS is quicker and less costly than CT and MRI, often being used at the patient's bedside, making it an attractive option for claustrophobic patients or those unable to tolerate being placed in the CT or MRI scanner.…”

Section: Overview Of Ceusmentioning

confidence: 99%

“…Unlike the contrast agents used with CT and MRI, which move into the extracellular space after injection, the agents used in CEUS remain purely intravascular and do not diffuse into the interstitium 5 . The spatial resolution of ultrasound (US) is often superior to that of CT or MRI, which is particularly useful in small masses 6 . The ability to image in real time can provide more complete information about a lesion's enhancement pattern during the entire postcontrast period and allows for the generation of time‐intensity curves.…”

Section: Overview Of Ceusmentioning

confidence: 99%

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Contrast‐Enhanced Ultrasound for the Evaluation of Renal Transplants

Kazmierski

Sharbidre

Robbin

et al. 2020

J of Ultrasound Medicine

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Contrast-enhanced ultrasound has emerged as a useful imaging modality for the evaluation of the transplant kidney. Advantages over traditional imaging modalities such as computed tomography and magnetic resonance imaging include the ability to visualize a lesion's enhancement pattern in real time, the lack of nephrotoxicity, and relatively low cost. Potential uses of contrast-enhanced ultrasound include characterization of solid and cystic transplant renal masses, assessment for pyelonephritis and identification of its complications, and evaluation of transplant complications in immediate and delayed settings. Contrast-enhanced ultrasound will likely play an increasing role for evaluating the transplant kidney, as an accurate diagnosis based on imaging can direct treatment and prevent unnecessary interventions. Key Words-angiomyolipoma; contrast-enhanced ultrasound; perirenal hematoma; posttransplantation lymphoproliferative disorder; renal cell carcinoma; renal transplant E nd-stage renal disease is a major source of morbidity and mortality in the United States. According to the 2018 United States Renal Data System, the prevalence of endstage renal disease has increased over time, having more than doubled between 1990 and 2016. 1 Although many patients with renal failure can be successfully treated with dialysis, renal transplantation is the definitive treatment for end-stage renal disease. Renal transplantation is more cost-effective than dialysis and results in an improved life expectancy. 2 Contrast-enhanced ultrasound (CEUS) is already frequently used for evaluation of the native kidneys. The 2019 "ACR-AIUM-SRU Practice Parameter for the Performance of Contrast-Enhanced Ultrasound" 3 provides guidelines for the appropriate use of CEUS in the kidney, including further characterization of solid and cystic renal lesions, assessment of renal perfusion, detection of renal abscesses in patients with pyelonephritis, and evaluation of the renal vasculature. More recently, CEUS has been used to evaluate the transplant kidney. Applications of CEUS in the transplant kidney include characterization of transplant renal masses (both benign and malignant), evaluation for infection and its potential complications, and assessment of perirenal collections and other posttransplant complications. Here, we provide a pictorial and descriptive review of the CEUS appearances of various entities that can affect the transplant kidney.

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Section: Overview Of Ceusmentioning

confidence: 99%

Section: Overview Of Ceusmentioning

confidence: 99%

Contrast‐Enhanced Ultrasound for the Evaluation of Renal Transplants

Kazmierski

Sharbidre

Robbin

et al. 2020

J of Ultrasound Medicine

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“…In musculoskeletal applications, CEUS represents a complementary investigative approach, which offers certain advantages in comparison to conventionally used diagnostic instruments such as DCE-MRI or DCE-CT. 34 Contrary to MRI, CT and X-ray examinations, the costeffective CEUS can be safely used in patients with renal impairment, without ionizing radiation or deposition of contrast agents in human body and fear of claustrophobia. 15,[35][36][37] Considering, among other things, the resolution and frame rate of CEUS, whose detail accuracy is superior to conventional MRI, CEUS may soon be able to support other time-consuming and cost-intensive medical investigations for various indications. 36…”

Section: Discussionmentioning

confidence: 99%

“…15,[35][36][37] Considering, among other things, the resolution and frame rate of CEUS, whose detail accuracy is superior to conventional MRI, CEUS may soon be able to support other time-consuming and cost-intensive medical investigations for various indications. 36…”

Section: Discussionmentioning

confidence: 99%

<p>Safety Profile of Musculoskeletal Contrast-Enhanced Ultrasound with Sulfur Hexafluoride Contrast Agent</p>

Fischer¹,

Kamtchouing²,

Strauch³

et al. 2020

TCRM

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These authors contributed equally to this workPurpose: Muscle, bone and tendon regeneration depend on the microperfusion of the corresponding tissue which can be quantified with contrast-enhanced ultrasound (CEUS) using sulfur hexafluoride contrast agent (SonoVue ® ). This study investigated the incidence of adverse events (AEs) in musculoskeletal patients and gives an overview of musculoskeletal CEUS applications. Patients and Methods: Based on 13 studies in a standardized monocentric setting, a total of 2268 CEUS examinations in 764 patients were performed and AEs due to the administration of sulfur hexafluoride contrast agent were classified as either mild, moderate or severe. Results: No fatal events occurred. AEs were reported in three cases, of which only one was classified as severe and two as mild. The total rate of all AEs was 0.13% and 0.04% for severe AEs. Conclusion: The present analysis confirms the safety of musculoskeletal CEUS using sulfur hexafluoride contrast agent with a lower rate of AEs than that reported for other contrast agents even in elderly patients with concomitant diseases.

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“…While both CEUS and PCT can provide information related to tumor perfusion, CEUS has advantages over PCT in terms of safety profile, cost, and lack of ionizing radiation (22); hence if CEUS is confirmed as a suitable alternate to PCT for quantification of tumor perfusion, it may be beneficial especially to patients with renal dysfunction or pediatric patients, and those enrolled in clinical trials who undergo repeat monitoring of response.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Contrast-Enhanced Ultrasound of Gastric Cancer: Correlation with Perfusion CT and Histopathology

et al. 2019

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Objective To assess the relationship between contrast-enhanced ultrasound (CEUS) parameters and perfusion CT (PCT) parameters of gastric cancers and their correlation with histologic features. Materials and Methods This prospective study was approved by our Institutional Review Board. We included 43 patients with pathologically-proven gastric cancers undergoing CEUS using SonoVue® (Bracco) and PCT on the same day. Correlation between the CEUS parameters (peak intensity [PI], area under the curve [AUC], rise time [RT] from 10% to 90% of PI, time to peak [TTP US ], and mean transit time [MTT US ]) and PCT parameters (blood flow, blood volume, TTP CT , MTT CT , and permeability surface product) of gastric cancers were analyzed using Spearman's rank correlation test. In cases of surgical resection, the CEUS and PCT parameters were compared according to histologic features using Mann-Whitney test. Results CEUS studies were of diagnostic quality in 88.4% (38/43) of patients. Among the CEUS parameters of gastric cancers, RT and TTP US showed significant positive correlations with TTP CT (rho = 0.327 and 0.374, p = 0.045 and 0.021, respectively); PI and AUC were significantly higher in well-differentiated or moderately-differentiated tumors (n = 4) than poorly-differentiated tumors (n = 18) ( p = 0.026 and 0.033, respectively), whereas MTT CT showed significant differences according to histologic types (poorly cohesive carcinoma [PCC] vs. non-PCC), T-staging (≤ T2 vs. ≥ T3), N-staging (N0 vs. N-positive), and epidermal growth factor receptor expression (≤ faint vs. ≥ moderate staining) ( p values < 0.05). Conclusion In patients with gastric cancers, CEUS is technically feasible for the quantification of tumor perfusion and may provide correlative and complementary information to that of PCT, which may allow prediction of histologic features.

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Practical advantages of contrast-enhanced ultrasound in abdominopelvic radiology

Cited by 22 publications

References 48 publications

Contrast‐Enhanced Ultrasound for the Evaluation of Renal Transplants

Contrast‐Enhanced Ultrasound for the Evaluation of Renal Transplants

<p>Safety Profile of Musculoskeletal Contrast-Enhanced Ultrasound with Sulfur Hexafluoride Contrast Agent</p>

Dynamic Contrast-Enhanced Ultrasound of Gastric Cancer: Correlation with Perfusion CT and Histopathology

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