“…In contrast, our study involved preprocessing to extract brain morphometry features, and the limited number of qubits required for VQCs hindered us from training the model using all the features, potentially leading to information loss. To address these challenges, hybrid approaches that combine classical and quantum machine learning [25,26] and employ techniques such as quanvolutional neural networks [37,38] or data reuploading [39] could potentially yield better results. In addition, our study did not demonstrate the clinical utility of age prediction and gender classification, which may require disease-specific or atypical data.…”