Practicability of the Inulin Plasma Single-Shot Clearance1

Gretz, Norbert; Ecker-Tschirner, K. H.; Kühnle, H.F.; Dahl, Kari; Kirschfink, Michael; Drescher, Petra; Lasserre, J. J.; Strauch, M

doi:10.1159/000418757

Cited by 21 publications

(9 citation statements)

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“…Different values were used according to age and sex [12]. In 12 patients inulin clearance using the single-shot technique was also measured [13] and the excretion of various urinary proteins in 24-h urine samples were measured: albumin α 1 -microglobuline (AMG) and TammHorsfall protein (THP) by enzyme-linked immunosorbent assay (Synelisa, Freiburg, Germany) and N-acetylglucosaminidase (NAG) by colorimetric assay with cresolsulfthalein (Boehringer, Mannheim, Germany). Ninety healthy children were analyzed as a reference group [14].…”

Section: Methodsmentioning

confidence: 99%

Kidney growth and renal function in unilateral multicystic dysplastic kidney disease

John

Rudnik‐Schöneborn

Zerres

et al. 1998

Pediatric Nephrology

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The natural history of multicystic dysplastic kidney (MCDK) is not well established. We analyzed kidney growth and renal function in 33 children with prenatally diagnosed unilateral MCDK in a long-term study. The mean observation period was 4.9 years with a range of 1-11.6 years. Abnormalities of the contralateral kidney were found in 10 of 33 patients (30%): ureteropelvic junction obstruction (5), ureterovesical junction obstruction (2), and vesicoureteral reflux (3). In 6 children the dysplastic kidney had been removed. Complete involution was observed in 48% and a decrease of size in 33% of 27 dysplastic kidneys. At the time of last examination, 27 of 29 children showed a volume of the contralateral kidney above the normal range (>145%). Hypertrophy of the contralateral kidney, defined as kidney length above 2 standard deviation scores (SDS), was seen in 24% of 33 children at birth, thus showing that hypertrophy of the contralateral kidney starts in utero and continues throughout childhood. The extent of contralateral hypertrophy was independent of associated abnormalities in this study. Mean creatinine was increased in the whole group (mean +1.13 SDS). Calculated creatinine clearance in 21 patients over 2 years was within normal limits, with a median of 102 ml/min per 1.73 m2 (range 84-143). Based on the results of this and previous studies, nephrectomy cannot be recommended in typical cases, but a regular follow-up of these patients seems necessary.

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Section: Methodsmentioning

confidence: 99%

Kidney growth and renal function in unilateral multicystic dysplastic kidney disease

John

Rudnik‐Schöneborn

Zerres

et al. 1998

Pediatric Nephrology

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“…This clearance-marker has the property of being water-soluble at room-temperatures (2,3). It may therefore be applied in constant-infusion and single-injection experiments directly (4,5). Although the chemically and clinically relevant properties of sinistrin are already well established, there still are open questions concerning the kinetic methodology.…”

Section: Introductionmentioning

confidence: 99%

Determination of the Glomerular Filtration Rate by Identification of Sinistrin Kinetics

Estelberger

Petek²,

Zitta³

et al. 1995

CCLM

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Summary: A computer-based method of system identification and estimation of parameter variance for two-compartment models matched to dynamic sinistrin concentration profiles for the determination of glomerular filtration rate is described. Thereby a procedure for the judgment of the optimal sampling time horizon is presented. Since single-injection techniques are suspected of yielding systematic overestimation of the glomerular filtration rate, a method is demonstrated confirming that such a technique employing sinistrin kinetics can be used to correctly determine the glomerular filtration rate.

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“…In addition, no optimal sampling strategies were developed in the study of Swinkels et al (4 ), and the model was not validated. Several other authors have used the slope clearance method instead of Bayesian estimation to simplify the inulin single-injection method for the determination of GFR in adults (23)(24)(25)(26)(27)(28). The slope clearance method is based on calculation of the area under the curve by the slope (rate constant) and the extrapolated inulin concentration at 0 min (y-intercept), but in nearly all those studies, no optimal sampling times were determined and the simplified method was not validated.…”

Section: Discussionmentioning

confidence: 99%

Optimal Sampling Strategies to Assess Inulin Clearance in Children by the Inulin Single-Injection Method

et al. 2003

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Practicability of the Inulin Plasma Single-Shot Clearance1

Cited by 21 publications

References 0 publications

Kidney growth and renal function in unilateral multicystic dysplastic kidney disease

Kidney growth and renal function in unilateral multicystic dysplastic kidney disease

Determination of the Glomerular Filtration Rate by Identification of Sinistrin Kinetics

Optimal Sampling Strategies to Assess Inulin Clearance in Children by the Inulin Single-Injection Method

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