Pr�fung der Festigkeitseigenschaften von Rattenhaut in Abh�ngigkeit von Lebensalter und Geschlecht

Vogel, H. Gerhard; Kobelt, Dennis; Korting, G. W.; Holzmann, W.

doi:10.1007/bf00520344

Cited by 21 publications

(2 citation statements)

References 41 publications

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“…As found by us (Holzmann et al, 1971;Vogel, 1972aVogel, , b, c, 1974bVogel et al, 1970), and with a different approach by Ridge and Wright, 1966, tensile strength and elasticity modulus of skin show a sharp increase until puberty in rats and human beings due to the maturation process which is fol lowed by a slow decrease due to the ageing process. These changes are paralleled by the content of insoluble collagen (Vogel, 1972a(Vogel, , b, c, 1974b.…”

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confidence: 84%

Strain of Rat Skin at Constant Load (Creep Experiments) Influence of Age and Desmotropic Agents

Hg¹

1977

Gerontology

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Creep experiments were performed on skin strips of rats of various ages (4 weeks to 2 years) and of rats treated with prednisolone acetate or D-penicillamine for 10 days. In one specimen of back skin the ultimate load and tensile strength was measured at an extension rate of 5 cm/min. 50 or 25% of the ultimate load was applied to other specimens of the same skin area. Strain (% extension), time until break, and ultimate extension rate were measured in these samples. The constant load was applied either in a continuous or an intermittent manner. The maturation process (up to an age of 1 year) induced an increase of tensile strength and of ultimate strain followed by a decrease due to the ageing process. Time until break was increased and ultimate extension rate was decreased during the whole life span. These values did not show a maximum or minimum. D-Penicillamine decreased tensile strength, decreased the ultimate strain, shortened the time until break at constant load and increased the ultimate extension rate. Prednisolone increased tensile strength and induced some decrease of ultimate strain and time until break. It was concluded that phenomena like creep indicating the viscosity of connective tissue do not resemble those parameters indicating elasticity behaviour.

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confidence: 84%

Strain of Rat Skin at Constant Load (Creep Experiments) Influence of Age and Desmotropic Agents

Hg¹

1977

Gerontology

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“…Most of the authors describe a decrease of the mechanical parameters with age (Melick and Miller, 1966;Evans, 1973;Horak and Nilsson, 1975;Burstein, et aL, 1976;Lindahl, 1976;Stein and Granik, 1976). In earlier studies (Holzmann et aL, 1971;Vogel et al, 1970), we could show that in human and rat skin the characteristic time course of an in crease was followed by a decrease in mechanical parameters. After the maturation period, a maximum of all parameters, e.g.…”

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confidence: 88%

Influence of Maturation and Aging on Mechanical and Biochemical Parameters of Rat Bone

Hg¹

1979

Gerontology

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The influence of maturation and senescence on the mechanical strength of bone was studied in rats by measuring the breaking load of the femur shaft and calculating the breaking strength. Strength of cartilage was studied by determining the ultimate load of femoral epiphyseal plate. A sharp increase of all mechanical parameters was found between the age of 1 and 4 months which was attributed to a maturation process. The maximum was achieved at 1 year followed by a decrease in all parameters. This was considered to reflect the aging or senescence process. The following biochemical parameters were determined in the same specimens: collagen and its soluble fractions, glycosaminoglycans, the fractions thereof, and elastin. The content of insoluble collagen was very closely correlated to the strength data, thus demonstrating an increase between 1 and 4 months, a plateau up to 1 year and a decrease at 2 years. During the maturation process, the glycosaminoglycans, especially the chondroitin sulfates, fell considerably. But also during the aging period, a further decrease was noted. The elastin content fell only slightly during the whole life span. The excellent correlation between strength parameters and content of insoluble collagen as found previously in skin could thus be confirmed. Strength of bone is apparently not dependent on the content of glycosaminoglycans and elastin. This indicates the major role of insoluble collagen for the mechanical properties of connective and supporting tissue. The studies presented here show that in rat bone the senescence process can be separated from the maturation process.

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Pharmacological models in dermatology

Vogel

Schölkens

et al. 2002

Drug Discovery and Evaluation

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Pr�fung der Festigkeitseigenschaften von Rattenhaut in Abh�ngigkeit von Lebensalter und Geschlecht

Cited by 21 publications

References 41 publications

Strain of Rat Skin at Constant Load (Creep Experiments) Influence of Age and Desmotropic Agents

Strain of Rat Skin at Constant Load (Creep Experiments) Influence of Age and Desmotropic Agents

Influence of Maturation and Aging on Mechanical and Biochemical Parameters of Rat Bone

Pharmacological models in dermatology

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