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Calinisan, Joan H.; Chan, Steven R.; King, Alan; Chan, Philip J.

doi:10.1023/a:1014736805127

Cited by 39 publications

(25 citation statements)

References 29 publications

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“…After HPV18 exposure, hatching at the blastocyst stage can be disturbed ( 31 ). The current evidence from in vitro studies in blastocyst stage embryonic cells also demonstrates impaired embryo development ( 32 ). When mouse blastocysts are incubated with HPV-DNA-16 fragments, DNA fragmentation and apoptosis increases ( 32 ).…”

Section: Hpv Infected Male and Embryo Developmentmentioning

confidence: 99%

“…The current evidence from in vitro studies in blastocyst stage embryonic cells also demonstrates impaired embryo development ( 32 ). When mouse blastocysts are incubated with HPV-DNA-16 fragments, DNA fragmentation and apoptosis increases ( 32 ). Studies of patients undergoing ART also support the negative effect of HPV on human embryo development.…”

Section: Hpv Infected Male and Embryo Developmentmentioning

confidence: 99%

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The implications of male human papilloma virus infection in couples seeking assisted reproduction technologies

Çağlar

Garrido

2018

J Turkish German Gynecol Assoc

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Human papilloma virus (HPV) is one of the most common viral sexually-transmitted diseases worldwide. The prevalence of HPV is higher in infertile males when compared with fertile men and ranges between 10 and 35.7% in men affected by unexplained infertility. HPV can bind to spermatozoa and can potentially be transferred to fertilized oocytes. Viral detection in blastocysts and trophoblastic cells is associated with impaired embryo development and poor pregnancy outcomes. Nevertheless, attempts to eliminate HPV-DNA from sperm samples through routine washing techniques have failed. In assisted reproduction technologies (ART), intracytoplasmic sperm injection involves no natural selection of the sperm cell, which means that these procedures have a plausible risk of injecting sperm containing HPV. The possible detrimental effects of HPV on ART in couples with infected male partners are summarized in this review.

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Section: Hpv Infected Male and Embryo Developmentmentioning

confidence: 99%

Section: Hpv Infected Male and Embryo Developmentmentioning

confidence: 99%

The implications of male human papilloma virus infection in couples seeking assisted reproduction technologies

Çağlar

Garrido

2018

J Turkish German Gynecol Assoc

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“…Following expression of the E6/E7 genes, increased DNA fragmentation and trophoblast death were noted in blastocysts [ 62 – 64 ]. These findings were particularly associated with the HPV 16 subtype [ 63 , 64 ]. The rate of HPV-related trophoblastic apoptosis seems to be related to the growth of the embryo; that is, the apoptosis rate is 3-fold and 5.8-fold greater at 3 and 12 days after fertilization, respectively [ 65 ].…”

Section: Hpv and Fertilitymentioning

confidence: 99%

Human Papillomavirus Infection, Infertility, and Assisted Reproductive Outcomes

Pereira

Estes

et al. 2015

Journal of Pathogens

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The human papillomavirus (HPV) is a sexually transmitted infection common among men and women across all geographic and socioeconomic subgroups worldwide. Recent evidence suggests that HPV infection may affect fertility and alter the efficacy of assisted reproductive technologies. In men, HPV infection can affect sperm parameters, specifically motility. HPV-infected sperm can transmit viral DNA to oocytes, which may be expressed in the developing blastocyst. HPV can increase trophoblastic apoptosis and reduce the endometrial implantation of trophoblastic cells, thus increasing the theoretical risk of miscarriage. Vertical transmission of HPV during pregnancy may be involved in the pathophysiology of preterm rupture of membranes and spontaneous preterm birth. In patients undergoing intrauterine insemination for idiopathic infertility, HPV infection confers a lower pregnancy rate. In contrast, the evidence regarding any detrimental impact of HPV infection on IVF outcomes is inconclusive. It has been suggested that vaccination could potentially counter HPV-related sperm impairment, trophoblastic apoptosis, and spontaneous miscarriages; however, these conclusions are based on in vitro studies rather than large-scale epidemiological studies. Improvement in the understanding of HPV sperm infection mechanisms and HPV transmission into the oocyte and developing blastocyst may help explain idiopathic causes of infertility and miscarriage.

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“…As a result, there is now more interest in HPV prevalence among couples undergoing in vitro fertilization (IVF). A viral infection is also known to induce blastocyst apoptosis in animal embryos [12]. The scientific literature states that an HPV infection is associated with a higher rate of spontaneous fetal loss or underdevelopment when undergoing IVF [13,14] due to the possible transmission of the virus to oocytes during fertilization, which affects or induces the immune system response.…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus and Infertility

Jeršovienė

Gudlevičienė

Rimienė³

et al. 2019

Medicina

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Background and objectives. Human papillomavirus (HPV) is the most commonly sexually transmitted infection. Recent evidence suggests that an HPV infection may affect fertility. The aim of the study was to determine the prevalence of HPV infections among couples undergoing in vitro fertilization (IVF) and to identify their awareness of HPV. Material and Methods. A total of 200 samples were collected from couples who received IVF treatment during 2017–2018 in Vilnius University Hospital Santaros Klinikos (VUH SK) Santaros Fertility Centre (SFC). For HPV detection, cervical swabs from women and sperm samples from men were taken and a real time polymerase chain reaction (RT-PCR) was used for the identification of 14 high-risk HPV types. Sperm parameters were evaluated according to World Health Organization (WHO) recommendations for 2010. Research subjects answered an anonymous questionnaire to ascertain their knowledge of HPV. Results. After testing of HPV in couples undergoing IVF, it was found that 33 out of 100 couples (33%) were HPV positive. Of these, 19% of women (19/100) and 20% of men (20/100) tested positive. Using Fisher’s exact test, a statistically significant difference was found between HPV infections and abnormal sperm quality parameters (p = 0.023). Conclusions. HPV may have an impact in spermatogenesis, because an HPV infection was more frequently detected in men with abnormal sperm parameters. High-risk HPV 52 was the most common genotype among couples undergoing IVF treatment.

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Cited by 39 publications

References 29 publications

The implications of male human papilloma virus infection in couples seeking assisted reproduction technologies

The implications of male human papilloma virus infection in couples seeking assisted reproduction technologies

Human Papillomavirus Infection, Infertility, and Assisted Reproductive Outcomes

Human Papillomavirus and Infertility

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