PPIs as possible risk factor for copper deficiency myelopathy

Subacute combined degeneration of the spinal cord in vitamin B12and copper deficiency

“…The copper deficiency may also be induced by the use of denture cream 1. Furthermore, there was a drug history of high-dose proton pump inhibitors over 2 years 2. Other potential causes of copper deficiency such as Wilson’s disease, alcoholism or Menkes disease were excluded.…”

Proton Pump Inhibitor Prescription in Patients with Liver Cirrhosis: Indications in Theory and the Real World

“…Actually, evidences are accumulating on a range of possible side effects of PPIs [12][13][14][15][16][17][18][19][20][21][22][23][24][25] that vary from syndromes of malabsorption causing deficiencies -for example of iron, magnesium or copper [26], to osteoporosis or susceptibility to infections of the gastrointestinal tract or the respiratory system. Regarding the predisposition to infections, various are the hypotheses advanced to explain such susceptibility: by one side, the reduction of the dampening effect of gastric acid on the pathogenic intestinal flora and the consequent variations in the composition of the intestinal micro biota, and on the other maybe some direct effect on the modulation of the immune response, due to functional interference on the cells responsible for the innate immunity [27][28][29].…”